One-pot multicomponent synthesis of substituted 5,7-dihydro-1,6-naphthyridines and 5,6,7,8-tetrahydroquinolines

• Authors: Chao-Guo Yan , Qi-Fang Wang , Xi-Mei Cai , Jing Sun
• Languages of publication: EN

Abstracts

EN

An one-pot approach was developed for the synthesis of substituted 5,7-dihydro-1,6-naphthyridines and 5,6,7,8-tetrahydroquinolines with moderate to good yields. This pathway is a modified two-step synthesis of Kröhnke pyridine and involves a four-component tandem reaction of N-phenacylpyridinium bromide, aromatic aldehydes, substituted or nitrogen-containing cyclic ketones and a nitrogen source. This multi-component reaction is performed using microwave irradiation heating of the reaction substrates under an environment of NH4OAc/HOAc. [...]

Keywords

EN

Substituted dihydro-1,6-naphthyridines; 5,6,7,8-tetrahydroquionolines; Kröhnke synthesis; Microwave irradiation; One-pot multicomponent condensation

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2008
• Volume: 6
• Issue: 2
• Pages: 188-198

Dates

published

1 - 6 - 2008

online

17 - 4 - 2008

Contributors

author

Chao-Guo Yan

• College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China

author

Qi-Fang Wang

• College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China

author

Xi-Mei Cai

• College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China

author

Jing Sun

• College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, China

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Identifiers

DOI

10.2478/s11532-008-0003-x