Interaction of unmodified and partially silylated nanosilica with red blood cells

• Authors: Vladimir Gun’ko , Natalia Galagan , Irina Grytsenko , Vladimir Zarko , Olena Oranska , Vyacheslav Osaulenko , Viktor Bogatyrev , Vladimir Turov
• Languages of publication: EN

Abstracts

EN

Interaction of red blood cells (RBCs) with unmodified and partially (50%) silylated fumed silica A-300 (nanosilica)was studied by microscopic, XRD and thermally stimulated depolarisation current (TSDC) methods. Nanosilica at a low concentration C A-300C A-300 = 1 wt% all RBCs transform into shadow corpuscles because of 100% haemolysis. Partial (one-half) hydrophobization of nanosilica leads to reduction of the haemolytic effect in comparison with unmodified silica at the same concentrations. A certain portion of the TSDC spectra of the buffered suspensions with RBC/A-300 is independent of the amounts of silica. However, significant portions of the low-and high-temperature TSDC bands have a lower intensity at C A-300 = 1 wt% than that for RBCs alone or RBC/A-300 at C A-300 = 0.01 wt.% because of structural changes in RBCs. Results of microscopic and XRD investigations and calculations using the TSDC-and NMR-cryoporometry suggest that the intracellular structures in RBCs (both organic and aqueous components) depend on nanosilica concentration in the suspension. [...]

Keywords

EN

blood cells; morphology; nanoparticles; interaction; haemolysis

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2007
• Volume: 5
• Issue: 4
• Pages: 951-969

Dates

published

1 - 12 - 2007

online

12 - 9 - 2007

Contributors

author

Vladimir Gun’ko

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Natalia Galagan

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Irina Grytsenko

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Vladimir Zarko

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Olena Oranska

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Vyacheslav Osaulenko

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Viktor Bogatyrev

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

author

Vladimir Turov

• Institute of Surface Chemistry, 17 General Naumov Street, 03164, Kiev, Ukraine

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Identifiers

DOI

10.2478/s11532-007-0045-5