Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B

• Authors: Zholt Kormosh , Iryna Hunka , Yaroslav Bazel , Andriy Laganovsky , Iryna Mazurenko , Nataliya Kormosh
• Languages of publication: EN

Abstracts

EN

The potentiometric response characteristics of a diclofenac selective electrode, based on ion association in different plasticizers, were compared. The sensitivity, working range, detection limit and selectivity of membrane sensors demonstrated significant dependence on the type of plasticizers. The potentiometric unit presented a linear response toward diclofenac concentrations between 1 × 10−5 − 5 × 10−2 mol L−1, with slopes of approximately 60 mV dec−1, and exhibited a response time of 3 s. The potentiometric analysis of sodium diclofenac in pharmaceutical formulations was perfomed by the membrane electrode proposed and compared with the results of potentiometric titration given by the Pharmacopoeia of Ukraine. [...]

Keywords

EN

Diclofenac; potentiometry; membrane sensor; pharmaceutical preparations

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2007
• Volume: 5
• Issue: 3
• Pages: 813-823

Dates

published

1 - 9 - 2007

online

2 - 5 - 2007

Contributors

author

Zholt Kormosh

• Volyn State University, 43025, Lutsk, Ukraine

author

Iryna Hunka

• Volyn State University, 43025, Lutsk, Ukraine

author

Yaroslav Bazel

author

Andriy Laganovsky

• Volyn State University, 43025, Lutsk, Ukraine

author

Iryna Mazurenko

• Volyn State University, 43025, Lutsk, Ukraine

author

Nataliya Kormosh

• Lutsk Base Medical College, 43000, Lutsk, Ukraine

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Identifiers

DOI

10.2478/s11532-007-0024-x