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2007 | 5 | 2 | 496-507

Article title

Voltammetric quantitation at the mercury electrode of the anticholinergic drug flavoxate hydrochloride in bulk and in a pharmaceutical formulation


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Flavoxate hydrochloride, 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4-H-chromene-8-carboxylate, is a smooth muscle antispasmodic. Its electrochemical behavior was studied at the mercury electrode in buffered solutions containing 30% (v/v) methanol using dc-polarography, differential-pulse polarography, cyclic voltammetry, and linear sweep-and square-wave adsorptive stripping voltammetry. Sensitive and precise procedures were developed for determination of bulk flavoxate hydrochloride and in the pharmaceutical formulation Genurin® S.F, without sample pretreatment or extraction. Limits of quantitation (LOQ) of 1 × 10−5, 5 × 10−6, 1 × 10−8 and 1 × 10−9 M flavoxate hydrochloride were achieved by dc-polarography, differential-pulse polarography, linear sweep and square-wave adsorptive stripping voltammetric, respectively. [...]










Physical description


1 - 6 - 2007
2 - 2 - 2007


  • Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt
  • Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt
  • Department of Analytical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754, Nacer City-Cairo, Egypt


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