Copper(II) complexes of the antihypertensive drug nadolol

• Authors: Valentina Getova , Ivayla Pantcheva , Darvin Ivanov , Dimitar Mehandjiev , Vassil Skumryev , Panayot Bontchev
• Languages of publication: EN

Abstracts

EN

The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to formation of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL2·2Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2·H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. [...]

Keywords

EN

Copper(II) complexes; nadolol; β-blocker

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2007
• Volume: 5
• Issue: 1
• Pages: 118-131

Dates

published

1 - 3 - 2007

online

1 - 3 - 2007

Contributors

author

Valentina Getova

• Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria

author

Ivayla Pantcheva

• Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria

author

Darvin Ivanov

• Faculty of Pharmacy, Medical University — Sofia, Sofia, 1000, Bulgaria

author

Dimitar Mehandjiev

• Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria

author

Vassil Skumryev

• Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Autònoma de Barcelona, 08193, Bellaterra (Barcelona), Spain

author

Panayot Bontchev

• Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria

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Identifiers

DOI

10.2478/s11532-006-0070-9