Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2007 | 5 | 1 | 118-131

Article title

Copper(II) complexes of the antihypertensive drug nadolol


Title variants

Languages of publication



The complexation of the non-selective β-blocker nadolol, HL, 1 with copper(II) leads to formation of mono-and dinuclear complexes depending mainly on the metal-to-ligand molar ratio. The mononuclear violet complex CuL2·2Solv, 2, was obtained in a soluble form at metal-to-ligand molar ratio Cu(II): HL ≤ 1: 10 in methanolic or slightly alkaline aqueous solutions. The dinuclear green complex Cu2L2Cl2·H2O, 3 was synthesized at Cu(II): HL ≥ 1: 2 molar ratio in methanolic solutions. The complexes were studied using spectral (UV-Vis, FT-IR, EPR), magnetochemical, thermogravimetric methods and elemental analysis. In the complexes nadolol acts as a monoanionic bidentate ligand coordinated to copper(II) through the NH-and the deprotonated OH-groups of its aminoalcohol fragment. [...]











Physical description


1 - 3 - 2007
1 - 3 - 2007


  • Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria
  • Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria
  • Faculty of Pharmacy, Medical University — Sofia, Sofia, 1000, Bulgaria
  • Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria
  • Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Autònoma de Barcelona, 08193, Bellaterra (Barcelona), Spain
  • Faculty of Chemistry, Sofia University, Sofia 1164, Bulgaria


  • [1] A.V. Chobanian, G.L. Bakris, H.R. Black, W.C. Cushman, L.A. Green, J.L. Izzo, Jr, D.W. Jones, B.J. Materson, S. Oparil, J.T. Wright, Jr, E.J. Roccella and the National High Blood Pressure Education Program Coordination Committee: “Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure”, Hypertension, Vol. 42, (2003), pp. 1206–1252. http://dx.doi.org/10.1161/01.HYP.0000107251.49515.c2[Crossref]
  • [2] L.C. Neri, H.L. Johansen, D. Hewitt, J. Marier and N. Langner: “Magnesium and Certain Other Elements and Cardiovascular Disease”, Sci. Total Environ., Vol. 42, (1985), pp. 49–75. http://dx.doi.org/10.1016/0048-9697(85)90007-5[Crossref]
  • [3] M.J. Kendrick, M.T. May, M.J. Plishka and K.D. Robinson: Metals in Biological Systems, Ellis Horwood, New York, 1992.
  • [4] K.T. Suzuki, A. Someya, Y. Komada and Y. Ogra: “Roles of Metallothionein in Copper Homeostasis: Responses to Cu-deficient Diets in Mice”, J. Inorg. Biochem., Vol. 88, (2002), pp. 173–182. http://dx.doi.org/10.1016/S0162-0134(01)00376-2[Crossref]
  • [5] J. Camakaris, I. Voskoboinik and J.F. Mercer: “Molecular Mechanisms of Copper Homeostasis”, Biochem. Biophys. Res. Commun., Vol. 261, (1999), pp. 225–232. http://dx.doi.org/10.1006/bbrc.1999.1073[Crossref]
  • [6] P.R. Bontchev, G. Gochev, B. Evtimova, H. Kadum and C. Nachev: “Copper(II) Interaction and Complexation with 1-[2(S)-3-mercapto-3-methylpropionyl]-L-proline (Captopril)”, J. Inorg. Biochem., Vol. 46, (1992), pp. 23–34. http://dx.doi.org/10.1016/0162-0134(92)80060-9[Crossref]
  • [7] P.R. Bontchev, B.B. Ivanova, R.P. Bontchev and D.R. Mehandjiev: “Complexes of Cu(II) with 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-piperazine (prazosin): Synthesis, Properties, Crystal Structure”, Polyhedron, Vol. 20, (2001), pp. 231–236. http://dx.doi.org/10.1016/S0277-5387(00)00639-2[Crossref]
  • [8] P.R. Bontchev and I.N. Pantcheva: “Copper(II) Complexes of Blood Pressure Active Drugs”, Transition Met. Chem., Vol. 27, (2002), pp. 1–21. http://dx.doi.org/10.1023/A:1013466529495[Crossref]
  • [9] P.R. Bontchev, I.N. Pantcheva, R.P. Bontchev, D.S. Ivanov and N.D. Danchev: “Copper(II) Complexes of the Beta-blocker Pindolol: Properties, Structure, Biological Activity”, BioMetals, Vol. 15, (2002), pp. 79–86. http://dx.doi.org/10.1023/A:1013128606238[Crossref]
  • [10] P.R. Bontchev, D.R. Mehandjiev, B.B. Ivanova and R.P. Bontchev: “A Mononuclear Complex of Copper(II) with the Calcium Channel Antagonist Nifedipine. Synthesis, Properties, Crystal Structure”, Transition Met. Chem., Vol. 28, (2003), pp. 745–748. http://dx.doi.org/10.1023/A:1026061029474[Crossref]
  • [11] V.T. Getova, R.P. Bontchev, D.R. Mehandjiev, V. Skumryev and P.R. Bontchev: “Copper(II) Complexes with 4-amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl Alcohol Hydrochloride (Clenbuterol). Crystal Structures of the Binuclear and Mononuclear Cu(II) Complexes with Clenbuterol”, Polyhedron, Vol. 24, (2005), pp. 1983–1990. http://dx.doi.org/10.1016/j.poly.2005.05.017[Crossref]
  • [12] V.T. Getova, R.P. Bontchev, D.R. Mehandjiev and P.R. Bontchev: “Complexes of 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone (Propafenone) with Copper(II). Crystal Structure of the Mononuclear Cu(II) Complex with Propafenone”, Polyhedron, Vol. 25, (2006), pp. 2254–2260. http://dx.doi.org/10.1016/j.poly.2006.01.027[Crossref]
  • [13] A.G. Dupont, P. Vanderniepen, A.M. Bossuyt, M.H. Jonckheer and R.O. Six: “Nadolol in Essential Hypertension: Effect on Ambulatory Blood Pressure, Renal Haemodynamics and Cardiac Function”, Br. J. Clin. Pharmacol., Vol. 20, (1985), pp. 93–99. [Crossref]
  • [14] D.J. Leggett: Computational Methods for the Determination of Formation Constants, Plenum, New York, 1985, p. 291.
  • [15] M.G. Arnaudov, B.B. Ivanova and Sh.G. Dinkov: “A Reducing-difference IR-spectral Study of 4-aminopyridine”, Centr. Eur. J. Chem., Vol. 2, (2004), pp. 589–597. http://dx.doi.org/10.2478/BF02482723[Crossref]
  • [16] B.B. Ivanova, D.L. Tsalev and M.G. Arnaudov: “Validation of Reducing-difference Procedure for the Interpretation of Non-polarized Infrared Spectra of N-component Solid Mixtures”, Talanta, Vol. 69, (2006), pp. 822–828. http://dx.doi.org/10.1016/j.talanta.2005.11.026[Crossref]
  • [17] M.G. Arnaudov and Sh. Dinkov: “IR-LD-spectral Study of Self-association Effects of 2-Amino-pyridine in Solution”, J. Mol. Struct., Vol. 476, (1999), pp. 235–241. http://dx.doi.org/10.1016/S0022-2860(98)00584-5[Crossref]
  • [18] B.B. Ivanova, V.D. Simeonov, M.G. Arnaudov and D.L. Tsalev: “Linear-dichroic Infrared Spectroscopy - Validation and Experimental Design of the New orientation Technique of Solid Samples as Suspension in Nematic Liquid Crystal”, Spectrochim. Acta A, (2006), in press. [WoS]
  • [19] J.K. Kauppinen, D.J. Moffatt, H.H. Mantsch and D.G. Cameron: “Fourier Self-Deconvolution: A Method for Resolving Intrinsically Overlapped Bands”, Appl. Spectrosc., Vol. 35, (1981), pp. 271–277. http://dx.doi.org/10.1366/0003702814732634[Crossref]
  • [20] A.J. Brown: “Spectral curve fitting for automatic hyperspectral data analysis”, IEEE Trans. Geosci. Remote Sens., Vol. 44, (2006), pp. 1601–1608. http://dx.doi.org/10.1109/TGRS.2006.870435[Crossref]
  • [21] M.I. Bulatov and I.P. Kalinkin: Prakticheskoe rukovodstvo po fotokolorimetricheskim i spektrofotometricheskim metodam analiza, Khimiya, Leningrad, 1978, Russ.
  • [22] P.R. Bontchev, H. Kadum, B. Evtimova, C. Nachev, E. Zhecheva, D. Mehandjiev and D. Ivanov: “Copper(II) Complexes of (1-[Isopropylamine]-3-[1-Naphthoxy]-2-Propanol) (propranolol)”, J. Inorg. Biochem., Vol. 48, (1992), pp. 153–161. http://dx.doi.org/10.1016/0162-0134(92)80024-P[Crossref]
  • [23] M. Laxer, A.C. Copomacchia and G.E. Hardee: “Intramolecular Hydrogen-bonding in Beta Adrenergic Blocking Agents”, Talanta, Vol. 28, (1981), pp. 973–976. http://dx.doi.org/10.1016/0039-9140(81)80240-8[Crossref]
  • [24] P.R. Bontchev, I.N. Pantcheva, T. Todorov, D.R. Mehandjiev and N.S. Savov: “Complexation of the Antihypertensive Drug Oxprenolol with Copper(II)”, J. Inorg. Biochem., Vol. 83, (2001), pp. 25–30. http://dx.doi.org/10.1016/S0162-0134(00)00126-4[Crossref]
  • [25] K. Trogmayer-Málik, I. Horváth and K. Burger: “The Effects of Configuration and Ring Size on the Stability of Copper(II) Chelates of Amino alcohols”, Inorg. Chim. Acta, Vol. 138, (1987), pp. 155–158. http://dx.doi.org/10.1016/S0020-1693(00)81200-1[Crossref]
  • [26] T. Lindgren, R. Sillanpää, T. Nortia and K. Pihlaja: “Copper(II) Complexes with Some 3-Amino-1-propanols”, Inorg. Chim. Acta, Vol. 73, (1983), pp. 153–158. http://dx.doi.org/10.1016/S0020-1693(00)90843-0[Crossref]
  • [27] N.A. Roeges: Guide to the Complete Interpretation of Infrared Spectra of Organic Structures, J. Wiley, New York, 1993.
  • [28] K. Nakamoto: Infrared and Raman Spectra of Inorganic and Coordination Compounds, 5th ed., Wiley, New York, Toronto, 1997.
  • [29] P. R. Bontchev, B.B. Ivanova, R.P. Bontchev and D.R. Mehandjiev: “Copper(II) Complexes of 1-[O-allylphenoxy]-3-[isopropylamino]-2-propanol (Alprenolol)”, J. Coord. Chem., Vol. 54, (2001), pp. 117–127. http://dx.doi.org/10.1080/00958970108027148[Crossref]
  • [30] Y. Ishimura, Y. Nonaka, Y. Nishida and S. Kida: “Copper(II) Complexes with Some Aliphatic Diaminealcohols”, Bull. Chem. Soc. Japan, Vol. 46, (1973), pp. 3728–3733. http://dx.doi.org/10.1246/bcsj.46.3728[Crossref]
  • [31] O. Kahn: Molecular Magnetism, Wiley, Chichester, UK, 1994.
  • [32] D.J. Hodgson: “Structural and Magnetic Properties of Binuclear Copper(II) Complexes”, Inorg. Chem., Vol. 15, (1976), pp. 3174–3175. http://dx.doi.org/10.1021/ic50166a051[Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.