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2007 | 5 | 1 | 32-54

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Interaction of fibrinogen with nanosilica


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Interaction of human plasma fibrinogen (HPF) with fumed nanosilica A-300 in a phosphate buffer solution (PBS) was studied using 1H NMR spectroscopy with layer-by-layer freezing-out of bulk and interfacial water in the temperature range of 210–273 K, TSDC (90 T FTIR, and UV spectroscopy methods. An increase in concentration of HPF in the PBS leads to a decrease in amounts of structured water (frozen at T FTIR and UV spectra show that the HPF adsorption on silica leads to structural changes of the protein molecules. These changes and formation of hybrid HPF/A-300 aggregates can increase the rate of clotting that is of importance on nanosilica application as a component of tourniquet preparations. [...]










Physical description


1 - 3 - 2007
1 - 3 - 2007


  • Institute of Surface Chemistry, 03164, Kiev, Ukraine
  • Institute of Surface Chemistry, 03164, Kiev, Ukraine
  • Institute of Surface Chemistry, 03164, Kiev, Ukraine
  • Institute of Surface Chemistry, 03164, Kiev, Ukraine
  • Institute of Surface Chemistry, 03164, Kiev, Ukraine
  • Institute of Surface Chemistry, 03164, Kiev, Ukraine


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