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2006 | 4 | 3 | 428-439
Article title

Experimental and modelling studies on antifungal compounds

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EN
Abstracts
EN
Antifungal activity of organic compounds (aromatic, salicylic derivatives, cinnamyl derivatives etc) on Fusarium Rosium (14 compounds) and Aspergillus niger (17 compounds) was studied and QSAR models were developed relating molecular descriptors with the observed activity. Back propagation Neural Network models and single and multiple regression models were tested for predicting the observed activity. The data fit as well as the predictive capability of the neural network models were satisfactory (R2 = 0.84, q2 = 0.73 for Fusarium Rosium and R2 = 0.75, q2 = 0.62 for Aspergillus niger). The descriptors used in the network for the former were X4 (connectivity) and Jhetv (topological); and TIC1 (information) and SPI (topological) for the latter fungus. Antifungal activities of these organic compounds were generally lower against the latter than with the former fungus.
Publisher
Journal
Year
Volume
4
Issue
3
Pages
428-439
Physical description
Dates
published
1 - 9 - 2006
online
1 - 9 - 2006
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-006-0022-4
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