Preparation of N-aryl-ketonitrone spin traps

• Authors: Inas Hassan , Robert Lauricella , Béatrice. Tuccio
• Languages of publication: EN

Abstracts

EN

The syntheses of seven N-aryl-C,C-dialkoxycarbonylnitrones 1–7, six of which were original, were achieved from the appropriate aryl-nitroso compounds. These ketonitrones were found to trap efficiently carbon-centred free radicals in aqueous media, yielding stable aminoxyl radicals whose EPR spectra lasted several days. The two penta-deuterated compounds 6 and 7 were also found to be efficient at trapping methoxyl radical. Their various spin adducts showed simple three line signals, very sensitive to the polarity of the environment. This study represents the very first use of linear ketonitrones as spin traps.

Keywords

EN

Ketonitrones; Spin trapping; free radicals; nitroxides; EPR spectroscopy

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2006
• Volume: 4
• Issue: 2
• Pages: 338-350

Dates

published

1 - 6 - 2006

online

1 - 6 - 2006

Contributors

author

Inas Hassan

• Laboratoire TRACES, Universités Aix-Marseille 1 et 3, 13397, Marseille, France

author

Robert Lauricella

• Laboratoire TRACES, Universités Aix-Marseille 1 et 3, 13397, Marseille, France

author

Béatrice. Tuccio

• Laboratoire TRACES, Universités Aix-Marseille 1 et 3, 13397, Marseille, France

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Identifiers

DOI

10.2478/s11532-006-0008-2