Since about 40 years has been made a number of changes in the field of rehabilitation patients with multiple sclerosis (MS). That was possible due to the results of numerous studies involving the verification of the effectiveness of various treatment programs or individual methods. In recent years, a number of clinical trials have shown the effectiveness and the significant impact of systematic rehabilitation on quality of life and extend the period of active life in a social and a professional aspect. It has been shown that the rehabilitation combined with pharmacological treatment helps to improve the physical, improve the patient’s well being, as well as to reduce the severity of symptoms. Rehabilitation gives the patient the possibility of a positive self-image production, enhances self-esteem and fitness, and thus causes a change in the perception of quality of life. The aim of the paper is to discuss the solutions currently used in the treatment of patients with MS.