Selected factors of fibrinolysis in the Buerger’s disease

• Authors: Piotr Terlecki , Marcin Feldo , Stanisław Przywara , Marek Iłżecki , Jan J. Kęsik , Grzegorz Borowski , Jacek Wroński , Tomasz Zubilewicz
• Languages of publication: EN

Abstracts

EN

Thrombangiitis obliterans (TAO marked by coexistence of thrombotic and inflammatory changes of neurovascular tract has evoked a considerable dispute concerning pathogenesis of this disease. The aim of the study was to define the level of activation of fibirinolitic system in course of TAO disease by means of determination its basic constituents as well as to examine the essence of level of fibrinolysis disorders in pathogenesis and development of this disease. Material and methods. Fifty patients with thrombangiitis obliterans (TAO), 30 patients with peripheral occlusive disease - PAOD (ASO) and 20 healthy volunteers (K) have been subjected to the examination. We determined the activity some factors of fibrinolysis: t-PA, PAI-1, PAP, plasminogen, α2-antiplasminogen, D-dimmer as well as euglobulin lysis time. The analysis comprised 7 features and 8 factors of variability: a membership to a group of patients, sex, age, smoking, aggravation of the disease within last 3 months, occurrence of Raynaud’s symptom, a degree of ischemia according to Fontaine, time the disease lasted. Results. The significant differences between the average were checked by means of t-Student test or variance analysis (ANOVA) and co-relation rate r (Pearson). We concluded that the average value of PAI-1 in the group TAO was significantly higher than in comparison with ASO group. The increased values were revealed in case of 76 % of patients. The euglobulin lysis time was vitally extended in case of 60% of patients in ASO group. In all three groups higher levels of α2-antiplasmin were detected in case of elderly patients compared to the younger ones. Conclusions. The obtained results allow us to ascertain the state of potentially weakened fibrinolysis in case of patients with Buerger’s disease as well as with PAOD.

Keywords

EN

Buerger’s disease; fibrinolysis

• Publisher: De Gruyter Open
• Journal: Polish Journal of Surgery
• Year: 2013
• Volume: 85
• Issue: 11
• Pages: 630-637

Dates

published

1 - 11 - 2013

online

31 - 12 - 2013

Contributors

author

Piotr Terlecki

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Marcin Feldo

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Stanisław Przywara

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Marek Iłżecki

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Jan J. Kęsik

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Grzegorz Borowski

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Jacek Wroński

• Department of Vascular Surgery and Angiology, Medical University in Lublin

author

Tomasz Zubilewicz

• Department of Vascular Surgery and Angiology, Medical University in Lublin

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Identifiers

DOI

10.2478/pjs-2013-0095