Introduction. Recent studies in this field are insufficient to determine the relationship between life quality and hemodialy-sis adequacy. The problem, which requires further analysis is the issue of verification of these relationships and the problem of the relationship between sleep disorders and hemodialysis indicators.Aim. The aim of this study is to determine the relationship between quality of life and sleep disorders occurring among patients with end stage renal disease (ESRD) treated with hemodialysis and the dialysis adequacy parameters.Material and methods. The survey was based on two standardized international scales: the Quality of Life Scale (SF-36) and the Pittsburg Sleep Quality Index (PSQI). The study was conducted among 150 patients (67 women and 83 men) treated with hemodialysis at the Fresenius center. All patients participating in the study were undergoing dialysis three times a week. The average value of Kt/V was 1.45 (SD=0.22) and URR ration 71.78 (SD=5.95).Results. The urea level prior to hemodialysis moderately strongly correlates with life energy deficit (r=-0.34, p=-0.049) and that the values of urea reduction ratio URR weakly correlates with the patient's conviction on restricting life's activity (SF-36) (r=0.18, p=0.046). The level of urea prior to dialysis correlates positively with the time of falling asleep in PSQI scale (r=-0.39, p=0.023).Conclusions. Patients with lower urea level before hemodialysis have a significantly higher vitality level. Higher fluctuations of urea concentrations before and after hemodialysis (higher urea reduction ratio URR) are associated with restrictions of physical activity in hemodialysis patients.