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2015 | 124 | 2 | 81-85

Article title

Evaluation of Gingival Conditions and Saliva TNF-α Concentration in Children with Acute Lymphoblastic Leukemia



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Introduction. Patients with the history of neoplastic disease in childhood and adolescence, successfully treated, are at higher risk in terms of their susceptibility to develop other diseases later in their lives.Aim. The purpose of study was to evaluate saliva TNF-α concentration in the children with acute lymphoblastic leukemia with reference to gingival inflammations.Material and methods. The investigation was carried out in the group of 78 children with ALL aged 2-18yrs and analogical in terms of age and gender group of healthy controls. Results. Gingival conditions were expressed as gingival index (GI). In the group of children with ALL mean GI determined in examination 1 was 0.084±0.34, in examination 2 GI=0.007±0.04 and in examination 3 mean GI=0.017±0.13. In the group of healthy controls GI=0.003±0.03. Saliva concentration of TNF-α determined in the group of children with ALL in examination 1 ranged 4.16-135.01pg/ml. In that group in examination 1, mean saliva TNF-α concentration was 36.9±32.6pg/ml. In the group of healthy children mean saliva TNF-α concentration was 52.1±107.64pg/ml.Conclusions. The authors, who observed various increases in the concentrations of TNF-α, IL-1α, IL-6, and IL-8 in the saliva and oral tissues in the patients consider that the proinflammatory cytokines in the saliva present in significantly higher concentrations in the future may have diagnostic and predicative value as replace indices of neoplastic transformations.Monitoring of prognostic factors affecting inflammations of the oral mucosa in children with ALL is likely to prevent complications to standard treatment and prolonged time of anticancer therapy. Early evaluation of those parameters can quicken recovery and strengthen patient's health. Close cooperation between dentists and pediatricians-hematologists is important in maintaining oral health and improve the quality of life of children suffering from neoplastic diseases.









Physical description


8 - 8 - 2014


  • Chair and Department of Paedodontics, Medical University, Lublin, Poland


  • 1. Zebrack BJ, Zevon MA, Turk N, et al. Psychological distress in long-term survivors of solid tumors diagnosed in childhood: a report from the childhood cancer survivor study. Pediatr Blood Cancer. 2007;49(1):47-51.[PubMed][Crossref]
  • 2. Bär G, Black PC, Gutjahr P, Stopfkuchenm H. Recovery kinetics of heart rate and oxygen uptake in long-term survivors of acute leukemia in childhood. Eur J Pediatr. 2007;166:1135-42.
  • 3. Małecka-Massalska T, Chara K, Gołębiowski P, et al. Methods of nutrition assessment in patients with head and neck cancer. Zdr Publ. 2013;123(3):253-4.
  • 4. Kamińska M, Ciszewski T, Bronikowska A, et al. The nurse's role in preventing and diminishing side effects after chemotherapy. Zdr Publ. 2013;123(4):325-9.
  • 5. Oeffinger KC, Hudson MM. Long-term Complications Following Childhood and Adolescent Cancer: Foundations for Providing Risk-based Health Care for Survivors. CA Cancer J Clin. 2004;54(4):208-36.[Crossref][PubMed]
  • 6. Brailo V, Vučićević-Boras V, Cekić-Arambaśin A, et al. The significance of salivary interleukin 6 and tumor necrosis factor alpha in patients with oral leukoplakia. Oral Oncol. 2006;42(4):370-3.[PubMed][WoS]
  • 7. Bültzingslöwen I, Sollecito TP, Fox PC, et al. Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103,3(suppl.1):S57.e1-S57.e15.[WoS]
  • 8. Vučićević Boras V, Brailo V, Lukač J, et al. Salivary interleukin-6 and tumor necrosis factor alpha in patients with drug-induced xerostomia. Oral Dis. 2006;2(5):509-11.[Crossref]
  • 9. Shankar AA, Routray S. Trends in salivary diagnostics - a 5-year review of oral oncology (2007-2011). Oral Oncol. 2012;48(6):e22-3.[WoS]
  • 10. Wu JY, Yi C, Chung HR, et al. Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol. 2010;46(4):226-31.[PubMed][Crossref]
  • 11. Scannapieco FA, Ng PBY, Hovey K, et al. Salivary Biomarkers Associated with Alveolar Bone Loss. Ann NY Acad Sci. 2007;1098:496-7.
  • 12. Winkler O, Hadnagy W, Idel H. Cytokines detectable in saliva of children as appropriate markers of local immunity of the oral cavity – an approach for the use in air pollution studies. Int J Hyg Environ Health, 2001;204(2-3):181-4.[Crossref][PubMed]
  • 13. Rhodus NL, Ho V, Miller CS, et al. NF-κB dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma. Cancer Detect Prev. 2005;29(1):42-5.[PubMed][Crossref]
  • 14. Laskus-Perendyk A, Grzegorczyk-Jażwińska A, Borakowska M. Zmiany w jamie ustnej pacjentów hospitalizowanych z powodu chorób krwi i układu krwiotwórczego. Nowa Stomatol. 2000;5(1/2):39-42.
  • 15. Dens F, Boute P, Otten J, et al. Dental caries, gingival health, and oral hygiene of long term survivors of paediatric malignant diseases. Arch Dis Child. 1995;72(2):129-32.[PubMed][Crossref]
  • 16. Fleming P, Kinirons MJ. Study of the dental health of children in remission from acute lymphoblastic leukemia in Northern Ireland. Community Dent Oral Epidemiol. 1993;21(5):309-12.[Crossref][PubMed]
  • 17. Kinirons MJ, Fleming P, Boyd D. Dental caries experience of children in remission from acute lymphoblastic leukaemia in relation to the duration of treatment and the period of time in remission. Int J Paediatr Dent. 1995;5(3):169-72.[PubMed]
  • 18. Sonis AL, Waber DP, Sallan S, Tarbell NJ. The oral health of long-term survivors of acute lymphoblastic lekaemia: a comparisonof three treatment modalites. Oral Oncol Eur J Cancer. 1995;31B(4):250-2.[Crossref]
  • 19. Avşar A, Elli M, Darka O, Pinarli G. Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(6):781-9.[Crossref][WoS]
  • 20. Uderzo C, Fraschini D, Balduzzi A, et al. Long-term effects of bone marrow transplantation on dental status in children with leukaemia. Bone Marrow Transplant. 1997;20(10):865-9.[PubMed]
  • 21. Jablonska E, Piotrowski L, Grabowska Z. Serum Levels of IL-1β, IL-6, TNF-β, sTNF-RI and CRP in Patients with Oral Cavity Cancer. Pathol Oncol Res. 1997;3(2):126-9.[Crossref]
  • 22. Philip M, Rowley DA, Schreiber H: Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol. 2004;14(6):433-9.[Crossref][PubMed]
  • 23. Sonis ST, Elting LS, Keefe D, et al. Mucositis Study Section of the Multinational Association for Supportive Care in Cancer; International Society for Oral Oncology: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology and consequences for patients. Cancer 2004;100(Suppl. 9):1995-2025.[PubMed]
  • 24. Webb RN, Cruse JM, Lewis RE. Differential cytokine and Toll-like receptor expression in leukemia. Exp Mol Pathol. 2007;83(3):464-70.[Crossref][PubMed]
  • 25. Rhodus NL, Cheng B, Myers S, et al. A comparison of the pro-inflammatory, NF-kappaB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients. Clin Immunol. 2005;114(3):278-83.

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