Top-down peptidomics of bodily fluids

• Authors: Claudia Martelli , Federica Iavarone , Federica Vincenzoni , Tiziana Cabras , Barbara Manconi , Claudia Desiderio , Irene Messana , Massimo Castagnola
• Languages of publication: EN

Abstracts

EN

The naturally occurring peptides, mainly arising
from the proteolytic cleavage of larger proteins, play
several functions within the body (e. g. antihypertensive,
immuno-modulatory, anti-microbial and antiviral,
mineral carriers). Their presence or the increase of their
concentration could be connected to different pathologies
and thereby some peptides could be useful biomarkers
for the diagnosis or prognosis of the disease. Peptidome
research, particularly within biological fluids, therefore
represents one of the most interesting and challenging
purposes of proteomics. In this review we describe the
current state-of-the-art in peptidomics-based studies
of several human bodily fluids (serum, plasma, urine,
cerebrospinal fluid, saliva, tears, seminal fluid, vitreous
humor, pancreatic juice), emphasizing the contribution
of top-down proteomic platforms to the deep structural
characterization of natural peptides and their posttranslational
modifications.

Keywords

EN

Top-down proteomics; serum; plasma; urine; cerebrospinal fluid; saliva; tears; seminal fluid; vitreous humor; pancreatic juice

• Publisher: De Gruyter Open
• Journal: Peptidomics
• Year: 2014
• Volume: 1
• Issue: 1

Dates

accepted

28 - 3 - 2014

received

5 - 12 - 2013

online

9 - 7 - 2014

Contributors

author

Claudia Martelli

• Istituto di Biochimica
  e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
  Sacro Cuore, Largo F. Vito, 00168, Roma, Italy

author

Federica Iavarone

• Istituto di Biochimica
  e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
  Sacro Cuore, Largo F. Vito, 00168, Roma, Italy

author

Federica Vincenzoni

• Istituto di Biochimica
  e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
  Sacro Cuore, Largo F. Vito, 00168, Roma, Italy

author

Tiziana Cabras

• Dipartimento di
  Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
  (CA), Italy

author

Barbara Manconi

• Dipartimento di
  Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
  (CA), Italy

author

Claudia Desiderio

• Istituto di Chimica del
  Riconoscimento Molecolare – UOS Roma, Consiglio Nazionale delle
  Ricerche, Roma, Italy

author

Irene Messana

• Dipartimento di
  Scienze della Vita e dell‘Ambiente, Università di Cagliari, Monserrato
  (CA), Italy

author

Massimo Castagnola

• Istituto di Biochimica
  e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del
  Sacro Cuore, Largo F. Vito, 00168, Roma, Italy
• Istituto di Chimica del
  Riconoscimento Molecolare – UOS Roma, Consiglio Nazionale delle
  Ricerche, Roma, Italy

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Identifiers

DOI

10.2478/ped-2014-0005