Chitosan microgels obtained by on-chip crosslinking reaction employing a microfluidic device

• Authors: Vanessa Zamora-Mora , Diego Velasco , Rebeca Hernández , Carmen Mijangos
• Languages of publication: EN

Abstracts

EN

In the present work, we report on the preparation
of microgels of chitosan crosslinked with sodium
tripolyphosphate (TPP) employing the microfluidics technique
(MF). To achieve this, several flow focusing geometries
were designed and tested. As a first step, a two-inlet
flow focusing geometry was employed to emulsify chitosan
and the crosslinking reaction was carried out offchip.
This procedure did not allow separating the resulting
chitosan microgels due to an incomplete crosslinking
reaction. A crosslinking reaction on-chip was studied as
an alternative. A four-inlet flow focusing geometrywas designed
in which three dispersed phases, chitosan 0.25%
(w/v), TPP 0.05% (w/v) and acetic acid 1% (v/v) and an
continuous phase mineral oil + Span 80 (3% w/v) were
employed. The flow rates for the continuous phase were
varied from 6.7 to 11.7 μL/min and chitosan microgels were
successfully obtained with average diameters from 68 to
42 μm. The average size of the microgels outside the MF
device decreased up to ~21% with respect to their size inside
the MF device due to partial expulsion of water from
the microgels when complete gelation occurred.

• Publisher: De Gruyter Open
• Journal: Optofluidics, Microfluidics and Nanofluidics
• Year: 2014
• Volume: 1
• Issue: 1

Dates

online

18 - 12 - 2014

accepted

19 - 9 - 2014

received

30 - 6 - 2014

Contributors

author

Vanessa Zamora-Mora

• Institute of Polymer
  Science and Technology, The Spanish National Research Council
  (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
• Department of Chemistry, University of Toronto, 80 Saint
  George Street, Toronto, Ontario M5S 3H6, Canada

author

Diego Velasco

• Department of Chemistry, University of Toronto, 80 Saint
  George Street, Toronto, Ontario M5S 3H6, Canada
• Department of Bioengineering, Universidad Carlos III de
  Madrid, Spain. Instituto de Investigación Sanitaria de la Fundación
  Jiménez Díaz, Madrid, Spain

author

Rebeca Hernández

• Institute of Polymer
  Science and Technology, The Spanish National Research Council
  (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain

author

Carmen Mijangos

• Institute of Polymer
  Science and Technology, The Spanish National Research Council
  (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain
• Department of Chemistry, University of Toronto, 80 Saint
  George Street, Toronto, Ontario M5S 3H6, Canada

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Identifiers

DOI

10.2478/optof-2014-0004