MicroRNAs are central to osteogenesis: a review
with a focus on cardiovascular calcification

• Authors: Sean Coffey , Gregory T Jones
• Languages of publication: EN

Abstracts

EN

Cardiovascular calcification, manifested by
coronary artery calcification and aortic valve stenosis, is a
widespread condition that is becoming more common with
the aging of the general population. No disease-modifying
therapies currently exist for any forms of cardiovascular
calcification. A number of similarities exist between
pathological calcification in cardiovascular tissue and
physiological calcification in bone, termed osteogenesis.
MicroRNAs are small noncoding RNAs that have been shown
to have multiple effects throughout the cardiovascular
system. In this review, we discuss the pre-clinical evidence
supporting a role for microRNAs in osteogenesis, with a focus
on cardiovascular calcification. The microRNAs with most
evidence implicating them in the disease process are the
miR-17~92 cluster, miR-23a/27a/24-2 family, miR-26a, miR-29b,
the miR-30 family, miR-31, miR-125b, miR-133a, miR-143/145,
miR-155, and miR-221/222. We also highlight the limitations
of current evidence in this field, such as the lack of studies
using high-throughput technologies.

Keywords

EN

MicroRNA (miR, miRNA); vascularcalcification; aortic valve stenosis; coronary arterycalcification; peripheral vascular disease

• Publisher: De Gruyter Open
• Journal: microRNA Diagnostics and Therapeutics
• Year: 2014
• Volume: 1
• Issue: 1

Dates

online

24 - 3 - 2015

accepted

30 - 10 - 2014

received

4 - 5 - 2014

Contributors

author

Sean Coffey

• OxVALVE Study, Room B15, Level
  0, Cardiac Investigations Annexe, John Radcliffe Hospital, Headley Way,
  Oxford OX3 9DU, United Kingdom
• Department of Medicine, University of Otago, Dunedin,
  New Zealand, and Research Fellow, Department of Cardiology,
  Oxford University Hospitals, Oxford, United Kingdom

author

Gregory T Jones

• Department of Surgery, University of Otago,
  Dunedin, New Zealand

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Identifiers

DOI

10.2478/micrnat-2014-0005