Reprogramming immune responses via microRNA modulation

• Authors: Juan R. Cubillos-Ruiz , Melanie R Rutkowski , Julia Tchou , Jose R. Conejo-Garcia
• Languages of publication: EN

Abstracts

EN

It is becoming increasingly clear that there are unique sets of miRNAs that have distinct governing roles in several aspects of both innate and adaptive immune responses. In addition, new tools allow selective modulation of the expression of individual miRNAs, both in vitro and in vivo. Here, we summarize recent advances in our understanding of how miRNAs drive the activity of immune cells, and how their modulation in vivo opens new avenues for diagnostic and therapeutic interventions in multiple diseases, from immunodeficiency to cancer. Recent contributions from our laboratory and other groups to novel formulations for miRNA mimetics are further discussed

Keywords

EN

microRNA; Immunotherapy; Tumor immunology; Adaptive immunity

• Publisher: De Gruyter Open
• Journal: microRNA Diagnostics and Therapeutics
• Year: 2014
• Volume: 1
• Issue: 1

Dates

published

1 - 1 - 2014

received

15 - 1 - 2013

accepted

15 - 3 - 2013

online

26 - 4 - 2013

Contributors

author

Juan R. Cubillos-Ruiz

• Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA / The Ragon Institute of MGH, MIT and Harvard. 149 13th Street, Charlestown, MA 02129, USA

author

Melanie R Rutkowski

• Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA

author

Julia Tchou

• Division of Endocrine and Oncologic Surgery, Department of Surgery, and the Rena Rowan Breast Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia 19104, USA

author

Jose R. Conejo-Garcia

• Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA

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Identifiers

DOI

10.2478/micrnat-2013-0001