Identification of a novel miRNA targeting CD146 for suppression of angiogenesis

• Authors: Sook Hyun Chung , Weiyong Shen , Mark Gillies
• Languages of publication: EN

Abstracts

EN

Angiogenesis is the pathological process of forming new blood vessels from pre-existing vessels. It is one of the main features of many conditions such as cancer and inflammatory diseases. MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression. Recent studies have suggested that miRNAs play a significant role in angiogenesis. The study from Wang et al reported a novel angiomiR, miRNA-329, and its negative correlation with CD 146 expression in angiogenesis. These in vitro and in vivo studies introduce an appealing new way of treating angiogenesis by targeting CD146.

Keywords

EN

Angiogenesis; MicroRNA; AngiomiR; miRNA--329

• Publisher: De Gruyter Open
• Journal: Non-coding RNAs in Endocrinology
• Year: 2014
• Volume: 1
• Issue: 1

Dates

published

1 - 7 - 2014

received

13 - 3 - 2014

online

26 - 7 - 2014

accepted

29 - 4 - 2014

Contributors

author

Sook Hyun Chung

• Macular Research Group, Clinical Ophthalmology and Eye Health, Save Sight Institute, The University of Sydney, Sydney, Australia

author

Weiyong Shen

• Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia

author

Mark Gillies

• Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia

References

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Identifiers

DOI

10.2478/micrnado-2014-0001