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Article title

Identification of a novel miRNA targeting CD146 for suppression of angiogenesis

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EN
Abstracts
EN
Angiogenesis is the pathological process of forming new blood vessels from pre-existing vessels. It is one of the main features of many conditions such as cancer and inflammatory diseases. MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression. Recent studies have suggested that miRNAs play a significant role in angiogenesis. The study from Wang et al reported a novel angiomiR, miRNA-329, and its negative correlation with CD 146 expression in angiogenesis. These in vitro and in vivo studies introduce an appealing new way of treating angiogenesis by targeting CD146.
Keywords
Publisher

Year
Volume
1
Issue
1
Physical description
Dates
published
1 - 7 - 2014
received
13 - 3 - 2014
online
26 - 7 - 2014
accepted
29 - 4 - 2014
Contributors
  • Macular Research Group, Clinical Ophthalmology and Eye Health, Save Sight Institute, The University of Sydney, Sydney, Australia, sook.chung@sydney.edu.au
author
  • Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia
author
  • Macular Research Group, Clinical Ophthalmology and Eye Health, the University of Sydney, Sydney, Australia
References
  • [1] De Falco, S., Antiangiogenesis therapy: an update after the first decade. Korean J Intern Med, 2014. 29(1): p. 1-11.[Crossref][PubMed]
  • [2] Crino, L. and G. Metro, Therapeutic options targeting angiogenesis in nonsmall cell lung cancer. Eur Respir Rev, 2014. 23(131): p. 79-91.
  • [3] Shord, S.S., et al., Understanding and managing the possible adverse effects associated with bevacizumab. Am J Health Syst Pharm, 2009. 66(11): p. 999-1013.[WoS][Crossref][PubMed]
  • [4] Wang, S. and E.N. Olson, AngiomiRs--key regulators of angiogenesis. Curr Opin Genet Dev, 2009. 19(3): p. 205-11.[PubMed][WoS][Crossref]
  • [5] Wang, S., et al., The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell, 2008. 15(2): p. 261-71.
  • [6] Kuehbacher, A., C. Urbich, and S. Dimmeler, Targeting microRNA expression to regulate angiogenesis. Trends Pharmacol Sci, 2008. 29(1): p. 12-5.[Crossref][WoS][PubMed]
  • [7] Rupaimoole, R., et al., MicroRNA therapeutics: principles, expectations, and challenges. Chin J Cancer, 2011. 30(6): p. 368-70.[Crossref]
  • [8] Wang, P., et al., MicroRNA 329 suppresses angiogenesis by targeting CD146. Molecular and cellular biology, 2013. 33(18): p. 3689-99.
  • [9] Bu, P., et al., Anti-CD146 monoclonal antibody AA98 inhibits angiogenesis via suppression of nuclear factor-kappaB activation. Molecular cancer therapeutics, 2006. 5(11): p. 2872-8.
  • [10] Kang, Y., et al., Knockdown of CD146 reduces the migration and proliferation of human endothelial cells. Cell research, 2006. 16(3): p. 313-8.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_micrnado-2014-0001
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