MicroRNAs: emerging regulators for development of pancreatic islet lineages

• Authors: Fang-Xu Jiang , Grant Morahan
• Languages of publication: EN

Abstracts

EN

MicroRNAs belong to a family of small (-23 nt) non-coding RNAs that mediate posttranscriptional gene silencing. They are emerging as important new regulators of differentiation and development. Knowledge of their role in pancreas and islet development, may help in developing a regenerative therapy for diabetes mellitus, a metabolic disorder affecting hundreds of millions of people worldwide. In this minireview, we summarize the latest evidence of the role these new regulators play in islet lineage development, aiming to attract more research into this important developmental regulators.

Keywords

EN

MicroRNAs; Islet progenitors; Differentiation

• Publisher: De Gruyter Open
• Journal: Non-coding RNAs in Endocrinology
• Year: 2014
• Volume: 1
• Issue: 1

Dates

published

1 - 7 - 2014

online

26 - 7 - 2014

accepted

28 - 11 - 2012

received

5 - 11 - 2012

Contributors

author

Fang-Xu Jiang

• Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia

author

Grant Morahan

• Centre for Diabetes Research, Western Australian Institute for Medical Research, and Centre for Medical Research, The University of Western Australia, Perth 6000, Australia

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Identifiers

DOI

10.2478/micrnado-2013-0002