Visfatin: a new player in rheumatic diseases

• Authors: Rodolfo Gómez , Ana Suarez , Amanda Villalvilla , Gabriel Herrero-Beaumont , Raquel Largo , David A. Young
• Languages of publication: EN

Abstracts

EN

During the last 50 years the number of overweight and obese people in
developed countries has increased dramatically. The consequences of this
excessive fat accumulation have been associated with a multitude of comorbidities,
mainly related to the cardiovascular system and glucose and
lipid metabolism. However, obesity also has an impact on other diseases,
as an enhancer of certain pathological aspects or as a susceptibility
factor, including certain rheumatic diseases such as rheumatoid arthritis
(RA), osteoarthritis (OA) and systemic lupus erythematosus (SLE). The link
between obesity and these rheumatic diseases has been purported to be
via the action of metabolic factors produced by adipose tissue, adipokines.
Among these adipokines are leptin and adiponectin, which have been
extensively studied. Our knowledge of the role of other relevant newer
adipokines, such as visfatin, in the arthritides is rapidly growing. Therefore,
in this review our aim is to summarize the current literature regarding the
association between visfatin and the most relevant rheumatic diseases.

Keywords

EN

Visfatin; Adipokines; Osteoarthritis; Rheumatoid arthritis; Cartilage

• Publisher: De Gruyter Open
• Journal: Immunometabolism
• Year: 2013
• Volume: 1
• Pages: 10-15

Dates

accepted

02 - 05 - 2013

received

14 - 04 - 2013

online

17 - 06 - 2013

Contributors

author

Rodolfo Gómez

• Musculoskeletal Research Group,
  Institute of Cellular Medicine,
  4th Floor Catherine Cookson Building,
  The Medical School, Newcastle University,
  Newcastle upon Tyne, NE2 4HH, UK

author

Ana Suarez

• Musculoskeletal Research Group,
  Institute of Cellular Medicine,
  4th Floor Catherine Cookson Building,
  The Medical School, Newcastle University,
  Newcastle upon Tyne, NE2 4HH, UK

author

Amanda Villalvilla

• Osteoarticular pathology laboratory,
  Institute Fundación Jimenez Diaz,
  Fundación Jiménez Díaz,
  Avd. Reyes Católicos,
  Madrid, Spain

author

Gabriel Herrero-Beaumont

• Osteoarticular pathology laboratory,
  Institute Fundación Jimenez Diaz,
  Fundación Jiménez Díaz,
  Avd. Reyes Católicos,
  Madrid, Spain

author

Raquel Largo

• Osteoarticular pathology laboratory,
  Institute Fundación Jimenez Diaz,
  Fundación Jiménez Díaz,
  Avd. Reyes Católicos,
  Madrid, Spain

author

David A. Young

• Musculoskeletal Research Group,
  Institute of Cellular Medicine,
  4th Floor Catherine Cookson Building,
  The Medical School, Newcastle University,
  Newcastle upon Tyne, NE2 4HH, UK

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Identifiers

DOI

10.2478/immun-2013-0002