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Journal

2014 | 15 | 2 | 116-119

Article title

Effects of L-Arginine Supplementation on Blood Pressure Reduction Pre-, Peri-, and Post-Cardiovascular Stimulus in Hypertensive Subjects with Different Angiotensin-Converting-Enzyme Genotypes

Content

Title variants

Languages of publication

EN

Abstracts

EN
Purpose. The present study investigated whether L-arginine supplementation reduces blood pressure (BP) in hypertensive subjects with different ACE genotypes. Methods. Eight male hypertensive patients received L-arginine (2 or 4 g/day) or a placebo for a period of 4 days prior an exercise test. Statistical analysis consisted of one-way analysis of variance. Results. L-arginine supplementation induced a statistically significant (p ⋋ 0.05) reduction in systolic BP measured during rest (reductions of 7.8% and 12.3% with 2 and 4 g/day, respectively), exercise (reductions of 11.8% and 10.4% with 2 and 4 g/day, respectively), and recovery (reductions of 11.7% and 10.7% with 2 and 4 g/day, respectively). The observed magnitude of BP reduction suggests an association with ACE polymorphism; a larger effect was seen with the II and DI genotypes compared with the DD genotype (II: 121 mmHg and DI: 133 mmHg vs. DD: 144 mmHg). Conclusions. The results showed that L-arginine supplementation at low doses was efficient in reducing BP and that vasodilator actions that occurred through the secretion of nitric oxide might be ACE genotype dependent.

Publisher

Journal

Year

Volume

15

Issue

2

Pages

116-119

Physical description

Dates

online
15 - 8 - 2014
accepted
23 - 4 - 2014
received
8 - 4 - 2013

Contributors

  • Department of Physiotherapy, Midwest State University of Parana Guarapuava, PR, Brazil
  • Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil
  • Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil
  • Physical Education Postgraduate Program, State University of Santa Catarina, Florianópolis, SC, Brazil
  • Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil
  • Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil
  • Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil
  • Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil
author
  • Department of Physical Education, Federal University of Paraná, Curitiba, PR, Brazil
author
  • Department of Physical Education, Federal University of Paraná, Curitiba, PR, Brazil

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_humo-2014-0012
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