Resistance Training in Type 2 Diabetic Patients Improves Uric Acid Levels

• Authors: Moisés S.S. R. Sousa , Francisco J.F. Saavedra , Gabriel R. Neto , Giovanni S. Novaes , Antonio C. R. Souza , Verônica P. Salerno , Jefferson S. Novaes
• Languages of publication: EN

Abstracts

EN

Resistance training (RT) can provide several benefits for individuals with Type 2 diabetes. The aim of this study was to investigate the effects of resistance training on the strength levels and uric acid (UA) concentration in individuals with Type 2 diabetes. The study included 68 patients (57.7±9.0 years) that participated in an organized program of RT for 12 weeks. The volunteers were divided into two groups: an experimental group (EG; n=34) that performed the resistance training program consisting of seven exercises executed in an alternating order based on segments; and a control group (CG; n=34) that maintained their normal daily life activities. Muscle strength and uric acid were measured both pre- and post-experiment. The results showed a significant increase in strength of the subjects in the EG for all exercises included in the study (p<0.001). Comparing the strength levels of the post-test, intergroup differences were found in supine sitting (p<0.001), leg extension (p<0.001), shoulder press (p<0.001), leg curl (p=0.001), seated row (p<0.001), leg press (p=0.001) and high pulley (p<0.001). The measured uric acid was significantly increased in both experimental and control groups (p<0.001 and p=0.001, respectively). The intergroup comparison showed a significant increase for the EG (p=0.024). We conclude that the training program was effective for strength gains despite an increase in uric acid in Type 2 diabetics.

Keywords

EN

muscular strength; uric acid; diabetes; resistance training

• Publisher: De Gruyter Open
• Journal: Journal of Human Kinetics
• Year: 2014
• Volume: 43
• Issue: 1
• Pages: 17-24

Dates

published

1 - 12 - 2014

online

11 - 12 - 2014

Contributors

author

Moisés S.S. R. Sousa

• University of Trás-os-Montes and Alto Douro (UTAD); Doctoral Program in Sport Science – PORTUGAL
• State University of Pará (UEPA), Belém, Pará – BRAZIL
• Institution: State University of Pará. Physical Education - Graduate Program. Belém - Pará Address: Alameda Abraham Athias, n. 14 – Bairro do Marco Zip Code: 66093-570 – Town: Belém – Pará / Country: Brazil Phone: (55+91) 91456278

author

Francisco J.F. Saavedra

• University of Trás-os-Montes and Alto Douro (UTAD); Doctoral Program in Sport Science – PORTUGAL.

author

Gabriel R. Neto

• Federal University of Rio de Janeiro (UFRJ). Physical Education - Graduate Program. Rio de Janeiro, RJ – BRAZIL.

author

Giovanni S. Novaes

• University of Trás-os-Montes and Alto Douro (UTAD); Doctoral Program in Sport Science – PORTUGAL.

author

Antonio C. R. Souza

• University of Trás-os-Montes and Alto Douro (UTAD); Doctoral Program in Sport Science – PORTUGAL.

author

Verônica P. Salerno

• Federal University of Rio de Janeiro (UFRJ). Physical Education - Graduate Program. Rio de Janeiro, RJ – BRAZIL.

author

Jefferson S. Novaes

• Federal University of Rio de Janeiro (UFRJ). Physical Education - Graduate Program. Rio de Janeiro, RJ – BRAZIL.

References

• ACSM. American College Sports Medicine. ACSM guidelines for stress testing and prescription (8 ed.). Rio de janeiro: Guanabara Koogan; 2010a
• ACSM. Exercise and Type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and Type 2 diabetes. Med Sci Sports Exerc, 2010b; 42: 2282-2303
• Andersen H, Nielsen S, Mogensen CE, Jakobsen J. Muscle strength in Type 2 diabetes. Diabetes, 2004; 53: 1543-1548[Crossref][PubMed]
• Bove M, Carnevali L, Cicero AF, Grandi E, Gaddoni M, Noera G, Gaddi AV. Psychosocial factors and metabolic parameters: Is there any association in elderly people? The Massa Lombarda Project. Aging Ment Health, 2010; 14: 801-6[PubMed][Crossref][WoS]
• Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with Type 2 diabetes. Diabetes Care, 2002; 25: 2335-2341[Crossref][PubMed]
• Ciolac EG, Guimarães GV. Physical exercise and metabolic syndrome. Rev Bras Med Esporte, 2004; 10: 319-324[WoS]
• Cunha GS, Ribeiro JL, Oliveira AR. Overtraining: theories, diagnosis and markers. Rev Bras Med Esporte, 2006; 12: 297-302[Crossref]
• Franz MJ, Bantle JP, Beebe CA, Brunzell JD, Chiasson JL, Garg A, Holzmeister LA, Hoogwerf B, Mayer- Davis E, Mooradian AD. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care, 2002; 25: 148-198[PubMed][Crossref]
• Gleeson M. Biochemical and immunological markers of overtraining. J Sports Sci Med, 2002; 1: 31-41[PubMed]
• Hameed UA, Manzar D, Raza S, Shareef MY, Hussain ME. Resistance training leads to clinically meaningful improvements in control of glycemia and muscular strength in untrained middle-aged patients with type 2 diabetes mellitus. N Am J Med Sci, 2012; 4: 336-343[PubMed]
• Hunter GR, McCarthy JP, Bamman MM. Effects of resistance training on older adults. Sports Med, 2004; 34: 329-348[Crossref][PubMed]
• Kaminsky LA. ACSM's resource manual for Guidelines for exercise testing and prescription (5 ed.). Baltimore, MD: Lippincott Williams & Wilkins; 2006
• Kindermann W. Overtraining-an expression of faulty regulated development. translated from. Deutsche Zietschrift Fur Sportmedizin, 1986; 37: 238-245
• Kommoju UJ, Reddy BM. Genetic etiology of Type 2 diabetes mellitus: a review. Int J Diabetes Dev Ctries, 2011; 31: 51-64
• Kraemer WJ, Adams K, Cafarelli E, Dudley GA, Dooly C, Feigenbaum MS, Fleck SJ, Franklin B, Fry AC, Hoffman JR. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc, 2002; 34: 364-380[WoS][PubMed]
• Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. Eur J Epidemiol, 2003; 18: 523-530[PubMed]
• Oda E. Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population. Heart and vessels, 2013; 1-8[WoS]
• Rhea RM. Determining the magnitude of treatment effects in strength training research through the use the effect size. J Strength Cond Res, 2004; 18: 918-920[PubMed]
• Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, Lernmark A, Metzger BE, Nathan DM. Position statement executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care, 2011; 34: 1419-1423[PubMed][WoS][Crossref]
• Salehidoost R, Aminorroayai A, Zare M, Amini M. Is uric acid an indicator of metabolic syndrome in the first-degree relatives of patients with Type 2 diabetes? J Res Med Sci, 2012; 17: 1005-1010[PubMed]
• Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. Physical activity/exercise and type 2 diabetes. Diabetes Care, 2004; 27: 2518-2539[Crossref][PubMed]
• Sousa VD, Driessnack M, Mendes IAC. An overview of research designs relevant to nursing: Part 1: quantitative research designs. Rev Latino-Am Enfermagem, 2007; 15: 502-507[WoS]
• Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS. Elevated serum uric acid levels in metabolic syndrome: An active component or an innocent bystander? Metabolism, 2006; 55: 1293-301[Crossref]
• Urhausen A, Gabriel HH, Kindermann W. Impaired pituitary hormonal response to exhaustive exercise in overtrained endurance athletes. Med Sci Sports Exerc, 1998; 30: 407-414[PubMed][Crossref]
• Urhausen A, Kindermann W. Diagnosis of Overtraining: What Tools Do We Have? Sports Med, 2002; 32: 95-102[Crossref][PubMed]
• Zabaglia R, Oliveira AC, Urtado CB, Souza TMF. Effect of resistance training in people with diabetes mellitus. Rev Bras Prescr Fisiol Exerc, 2009; 3: 547-558
• Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SRJ. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci, 2003; 105: 425-430 [PubMed][Crossref]

Identifiers

DOI

10.2478/hukin-2014-0085