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2014 | 41 | 1 | 107-111

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Changes in Urinary 8-Hydroxydeoxyguanosine Levels During Heptathlon Race in Professional Female Athletes


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Acute strenuous exercise can induce a state of oxidative stress affecting the involved muscles. Heptathlon is a multi-event exercise of two days duration and can be considered an acute, intensive endurance exercise. The purpose of this study is to compare the oxidative stress response to heptathlon events day by day and to determine the impact of this type of exercise on oxidative stress biomarkers.The study subjects included eight heptathlon athletes who participated in the National First Class Republic competition in Egypt (October 19-21, 2011). Blood samples were collected at rest after exercise for two successive days and analyzed for malondialdehyde (MDA). Morning urine samples were collected one hour after exercise for each day and were analyzed for 8-hydroxydeoxyguanosine (8-OHdG). Results revealed a significant increase (p<0.05) in both plasma MDA and urine 8-OHdG levels after exercise regardless of the day. We concluded that exercise generates higher MDA levels compared to DNA strand breaks and oxidative DNA damage in athletes with antioxidant supplementation.









Physical description


1 - 12 - 2013
8 - 7 - 2014


  • Faculty of physical education for girls, Helwan University, Egypt.
  • Faculty of medicine, Al Azhar University, Cairo, Egypt.


  • Alessio M, Goldfarb AH, Cao G. Exercise-induced oxidative stress before and after vitamin C supplementation. Int J Sport Nutr,1997; 7(1): 1-9 Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med. Sci. Sports Exerc,2000; 32: 1576-1581
  • Banerjee AK, Mandal A, Chanda D, Chakraborti S. Oxidant, antioxidant and physical exercise. Mol Cell Biochem,2003; 253(1-2): 307-312
  • Bloomer RJ. Effect of exercise on oxidative stress biomarkers. Adv Clin Chem,2008; 46: 1-50[PubMed][Crossref]
  • Bloomer RJ, Smith WA. Oxidative stress in response to aerobic and anaerobic power testing: influence of exercise training and carnitine supplementation. Res Sports Med,2009; 17(1): 1-16[WoS][PubMed][Crossref]
  • Chevion S, Moran DS, Heled Y, Shani Y, Regev G, Abbou B, Berenshtein E, Stadtman E, Epstein Y. Plasma antioxidant status and cell injury after severe physical exercise. Proc Natl Acad Sci,2003; 100: 5119-5123[Crossref]
  • Davies KJ, Quintanilha AT, Brooks GA, Packer GA. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun,1982; 107 (4): 1198-1205[Crossref][PubMed]
  • Halliwell B, Cross CE. Oxygen-derived species: their relation to human disease and environmental stress. Environ Health Perspect,1994; 102 (Suppl 10): 5-12[PubMed][Crossref]
  • Hartmann A, Pfuhler S, Dennog C, Germadnik D, Pilger A, Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2-deoxyguanosine or induction of micronuclei. Free Radic Biol Med,1998; 24(2): 245-251
  • Inoue T, Mu Z, Sumikawa K, Adachi K, Okochi T. Effect of physical exercise on the content of 8-hydroxydeoxyguanosine in nuclear DNA prepared from human lymphocytes. Japanese Journal ofCancer Research,1993; 84: 725-750
  • Martarelli D, Pompei P. Oxidative stress and antioxidant changes during a 24-hours mountain bike endurance exercise in master athletes. J. Sports Med. Phys. Fitness,2009; 49: 122-127
  • Powers SK, Jackson MJ. Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production. Physiol Rev,2008; 88: 1243-1276[WoS][PubMed][Crossref]
  • Radak Z, Taylor AW, Ohno H, Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev,2001; 7: 90-107[PubMed]
  • Sumida S, Doi TT, Sakurai M, Yoshioka Y, Okamura K. Effect of a single bout of exercise and beta-carotene supplementation on the urinary excretion of 8-hydroxy-deoxyguanosine in humans. Free Radic Res, 1997; 27: 607-618
  • Fisher-Wellman K, Bel HK, Bloomer RJ. Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders. Oxidative Medicine and Cellular Longevity, 2009; 2: 43-51

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