Preferences help
enabled [disable] Abstract
Number of results
2014 | 1 | 1-5
Article title

Genetics of myocardial infarction in clinical practice. Is it ready for prime time?

Title variants
Languages of publication
Ischemic heart diseases are the leading cause of morbidity and mortality in developed countries, despite advances in cardiac care over the last few decades. Myocardial infarction is a complex, multifactorial disorder that is thought to be due to interactions between genetic and environmental factors. Recent rapid advances in molecular genetics techniques have identified a number of common genetic variants loosely associated with myocardial infarction, and highly promising, newly designed platforms should identify less common genetic variants with an even greater clinical impact. These discoveries have brought us to a stage at which we need to begin to consider how personalised genomic information should be incorporated into clinical practice in order to benefit individuals and society in general.
Physical description
2 - 10 - 2013
24 - 02 - 2014
5 - 6 - 2013
  • [1] A haplotype map of the human genome. Nature. 2005;437:1299-320
  • [2] Frazer KA, Ballinger DG, Cox DR, et al. A second generation human haplotype map of over 3.1 million snps. Nature. 2007;449:851-61[WoS]
  • [3] Morgan TM, Krumholz HM, Lifton RP, Spertus JA. Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA. 2007;297:1551-61[WoS]
  • [4] Cohen JC. Genetic approaches to coronary heart disease. Journal of the American College of Cardiology. 2006;48:A10-A4
  • [5] Samani NJ, Erdmann J, Hall AS, et al. Genomewide association analysis of coronary artery disease. N Engl J Med. 2007;357:443-53[WoS]
  • [6] Helgadottir A, Thorleifsson G, Manolescu A, et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 2007;316:1491-3
  • [7] McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488-91
  • [8] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-78[WoS]
  • [9] Shen GQ, Rao S, Martinelli N, et al. Association between four snps on chromosome 9p21 and myocardial infarction is replicated in an italian population. J Hum Genet. 2008;53:144-50
  • [10] Shen GQ, Li L, Rao S, et al. Four snps on chromosome 9p21 in a south korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler Thromb Vasc Biol. 2008;28:360-5[WoS]
  • [11] Schunkert H, Gotz A, Braund P, et al. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. Circulation. 2008;117:1675-84[WoS]
  • [12] Hinohara K, Nakajima T, Takahashi M, et al. Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in japanese and korean populations. J Hum Genet. 2008;53:357-9
  • [13] Horne BD, Carlquist JF, Muhlestein JB, Bair TL, Anderson JL. Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease. Circ Cardiovasc Genet. 2008;1:85-92[WoS]
  • [14] Assimes TL, Knowles JW, Basu A, et al. Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic advance study. Hum Mol Genet. 2008;17:2320-8
  • [15] Palomaki GE, Melillo S, Bradley LA. Association between 9p21 genomic markers and heart disease: A meta-analysis. JAMA. 2010;303:648-56[WoS]
  • [16] Schunkert H, Erdmann J, Samani NJ. Genetics of myocardial infarction: A progress report. Eur Heart J. 2010;31:918-25
  • [17] Ardissino D, Berzuini C, Merlini PA, et al. Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction. J Am Coll Cardiol. 2011;58:426-34
  • [18] Visel A, Zhu Y, May D, et al. Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 2010;464:409-12[WoS]
  • [19] Kathiresan S, Voight BF, Purcell S, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41:334-41[WoS]
  • [20] Erdmann J, Grosshennig A, Braund PS, et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 2009;41:280-2[WoS]
  • [21] Tregouet DA, Konig IR, Erdmann J, et al. Genome-wide haplotype association study identifies the slc22a3-lpal2-lpa gene cluster as a risk locus for coronary artery disease. Nat Genet. 2009;41:283-5
  • [22] Paynter NP, Chasman DI, Buring JE, Shiffman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med. 2009;150:65-72
  • [23] Brautbar A, Ballantyne CM, Lawson K, et al. Impact of adding a single allele in the 9p21 locus to traditional risk factors on reclassification of coronary heart disease risk and implications for lipid-modifying therapy in the atherosclerosis risk in communities study. Circ Cardiovasc Genet. 2009;2:279-85[WoS]
  • [24] Talmud PJ, Cooper JA, Palmen J, et al. Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of chd in healthy middle-aged men. Clin Chem. 2008;54:467-74[WoS]
  • [25] Kathiresan S, Melander O, Anevski D, et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med. 2008;358:1240-9[WoS]
  • [26] Morrison AC, Bare LA, Chambless LE, et al. Prediction of coronary heart disease risk using a genetic risk score: The atherosclerosis risk in communities study. Am J Epidemiol. 2007;166:28-35
  • [27] Aulchenko YS, Ripatti S, Lindqvist I, et al. Loci influencing lipid levels and coronary heart disease risk in 16 european population cohorts. Nat Genet. 2009;41:47-55[WoS]
  • [28] Paynter NP, Chasman DI, Pare G, et al. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA. 2010;303:631-7[WoS]
  • [29] Ripatti S, Tikkanen E, Orho-Melander M, et al. A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses. Lancet. 2010;376:1393-400[WoS]
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.