A diversity oriented, efficient and sustainable
synthetic protocol has been presented for the synthesis
of structurally diverse drug-like small heterocycles
with structural complexity. The present synthetic
strategy involves a three-component domino reaction of
2-aminobenzothiazoles, thiophene-2-carbaldehyde and
carbonyl compounds in the presence of a catalytic amount
of sulfamic acid as a recyclable ecofriendly acid catalyst.