Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results
2014 | 35 | 3 | 369-385

Article title

Numerical Analysis Of Mixing Under Low And High Frequency Pulsations At Serpentine Micromixers


Title variants

Languages of publication



The numerical investigation of the mixing process in complex geometry micromixers, as a function of various inlet conditions and various micromixer vibrations, was performed. The examined devices were two-dimensional (2D) and three-dimensional (3D) types of serpentine micromixers with two inlets. Entering fluids were perturbed with a wide range of the frequency (0 - 50 Hz) of pulsations. Additionally, mixing fluids also entered in the same or opposite phase of pulsations. The performed numerical calculations were 3D to capture the proximity of all the walls, which has a substantial influence on microchannel flow. The geometry of the 3D type serpentine micromixer corresponded to the physically existing device, characterised by excellent mixing properties but also a challenging production process (Malecha et al., 2009). It was shown that low-frequency perturbations could improve the average mixing efficiency of the 2D micromixer by only about 2% and additionally led to a disadvantageously non-uniform mixture quality in time. It was also shown that high-frequency mixing could level these fluctuations and more significantly improve the mixing quality. In the second part of the paper a faster and simplified method of evaluation of mixing quality was introduced. This method was based on calculating the length of the contact interface between mixing fluids. It was used to evaluate the 2D type serpentine micromixer performance under various types of vibrations and under a wide range of vibration frequencies.









Physical description


1 - 9 - 2014
1 - 1 - 2014
17 - 10 - 2014
20 - 7 - 2014
24 - 4 - 2014


  • University of New Hampshire, Program in Integrated Applied Mathematics, Durham, NH 03824, USA
  • Wrocław University of Technology, Department of Cryogenic, Aviation and Process Engineering, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Wrocław University of Technology, Faculty of Microsystem Electronics and Photonics, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland


  • Bałdyga J., Bourne, J. R., 1984. Mixing and fast chemical reaction-VIII: Initial deformation of material elements in isotropic, homogeneous turbulence. Chem. Eng. Sci., 39, 329-334. DOI: 10.1016/0009-2509(84)80031-7.[Crossref]
  • Batchelor G.K., 2000, An Introduction to Fluid Dynamics. Cambridge University Press, Cambridge (UK).
  • Dziuban J.A., Mróz J., Szczygielska M., Małachowski M., Górecka-Drzazga A., Walczak R., Buła W., Zalewski D., Nieradko L., Łysko J., Kosztur J., Kowalski P., 2004. Portable gas chromatograph with integrated components. Sens. Actuators A, 115, 318-330. DOI: 10.1016/j.sna.2004.04.028.[Crossref]
  • Glasgow I., Aubry N., 2003. Enhancement of microfluidic mixing using time pulsing. Lab Chip, 3, 114-120. DOI: 10.1039/B302569A.[Crossref]
  • Gravesen P., Branebjerg J., Jensen O.S., 1993. Microfluidics - A review. J. Micromech. Microeng., 3, 168-182. DOI: 10.1088/0960-1317/3/4/002.[Crossref]
  • Groß G., Thelemann T., Schneider S., Boskovic D., Kohler J., 2008. Fabrication and fluidic characterization of static micromixer made of low temperature cofired ceramic (LTCC). Chem. Eng. Sci., 63, 2773-2784.[WoS]
  • DOI:10.1016/j.ces.2008.02.030.[Crossref]
  • Hessel V., Lowe H., Schonfeld F., 2005. Micromixer a review on passive and active mixing principles. Chem. Eng. Sci., 60, 2479-2501. DOI: 10.1016/j.ces.2004.11.033.[Crossref]
  • Kudela H., Malecha Z.M., 2009. Eruption of a boundary layer induced by a 2D vortex patch. Fluid Dyn. Res., 41, 055502. DOI: 10.1088/0169-5983/41/5/055502.[Crossref]
  • Liu P., Li X., Greenspoon S.A., Scherer J.R., Mathies R.A., 2011. Integrated DNA purification, PCR, sample cleanup, and capillary electrophoresis microchip for forensic human identification. Lab Chip, 11, 1041-1048. DOI: 10.1039/c0lc00533a.[Crossref][WoS]
  • Malecha K., 2013. A PDMS-LTCC bonding using atmospheric pressure plasma for microsystem applications. Sens. Actuators B, 181, 486-493. DOI: 10.1016/j.snb.2013.01.094.[Crossref][WoS]
  • Malecha K., Golonka L.J., Bałdyga J., Jasińska M., Sobieszuk P., 2009. Serpentine microfluidic mixer made in LTCC. Sens. Actuators B, 143, 400-413. DOI: 10.1016/j.snb.2009.08.010.[Crossref][WoS]
  • Malecha K., Pijanowska D.G., Golonka L.J., Kurek P., 2011. Low temperature co-fired ceramic (LTCC)-based biosensor for continuous glucose monitoring. Sens. Actuators B, 155, 923-929. DOI: 10.1016/j.snb.2011.01.002.[Crossref]
  • Malecha Z.M., Chorowski M., Polinski J., 2013. Numerical study of emergency cold helium relief into tunnel using a simplified 3D model. Cryogenics, 57, 181-188. DOI: 10.1016/j.cryogenics.2013.07.006.[Crossref][WoS]
  • Malecha Z.M., Mirosław L., Tomczak T., Koza Z., Matyka M., Tarnawski W., Szczerba D., 2011. GPU-based simulation of 3D blood flow in abdominal aorta using openfoam. Archives of Mechanics, 63, 137-161.
  • Manz A., Graber N., Widmer M., 1990. Miniaturized total chemical analysis systems: A novel concept for chemical sensing. Sens. Actuators B, 1, 244-248. DOI: 10.1016/0925-4005(90)80209-I.[Crossref]
  • Monnery W.D., Svrcek W.Y., Mehrotra A.K., 1995. Viscosity: A critical review of practical predictive and correlative methods. Can. J. Chem. Eng., 73, 3-40. DOI: 10.1002/cjce.5450730103.[Crossref]
  • Neild A., Wah Ng T., Sheard G.J., Powers M., Oberti S., 2010. Swirl mixing at microfluidic junctions due to low frequency side channel fluidic perturbations. Sens. Actuators B, 150, 811-818. DOI: 10.1016/j.snb.2010.08.027.[Crossref][WoS]
  • Nguyen N.-T., 2012. Micromixers: Fundamentals, design and fabrication. 2nd edition, Elsevier, Oxford (UK).
  • Nguyen N.-T., Wu Z., 2005. Micromixers - A review. J. Micromech. Microeng., 15, R1-R16. DOI: 10.1088/0960-1317/15/2/R01.[Crossref]
  • Oberti S., Neild A., Wah Ng T., 2009. Microfluidic mixing under low frequency vibration. Lab Chip, 9, 1435-1438. DOI: 10.1039/b819739c.[WoS][Crossref]
  • OpenFOAM, 2009. The Open Source CFD Toolbox User Guide.
  • Ottino J.M., Wiggins S., 2004. Introduction: Mixing in microfluidics. Phil. Trans. R. Soc. Lond. A, 362, 923-935. DOI: 10.1098/rsta.2003.1355.[Crossref]
  • Wiggins S., Ottino J.M., 2004. Foundations of chaotic mixing. Phil. Trans. R. Soc. Lond. A, 362, 937-970. DOI: 10.1098/rsta.2003.1356.[Crossref]
  • Yi M., Bau H.H., 2003. The kinematics of bend-induced mixing in microconduits. Int. J. Heat Fluid Flow, 24, 645-656. DOI: 10.1016/S0142-727X(03)00026-2. [Crossref]

Document Type

Publication order reference


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.