Effect of N-(m-bromoanilinomethyl)-p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model

• Authors: Jarogniew J. Luszczki , Ewa Marzeda , Maria W. Kondrat-Wrobel , Daniel Pyrka , Sergey L. Kocharov , Magdalena Florek-Luszczki
• Languages of publication: EN

Abstracts

EN

The purpose of this study was to determine the effects of N-(m-bromoanilinomethyl)- p-isopropoxyphenylsuccinimide (BAM-IPPS - a new succinimide derivative) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) in the mouse maximal electroshock (MES)-induced tonic seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. BAM-IPPS administered (i.p.) at a dose of 150 mg/kg significantly elevated the threshold for electroconvulsions in mice (P<0.05). Lower doses of BAM-IPPS (50 and 100 mg/kg) had no significant impact on the threshold for electroconvulsions in mice. Moreover, BAM-IPPS (100 mg/kg) did not significantly affect the anticonvulsant potency of CBZ, PB, PHT and VPA in the mouse MES model. BAM-IPPS elevated the threshold for electroconvulsions in mice in a dosedependent manner. However, BAM-IPPS (100 mg/kg) did not affect the anticonvulsant action of various classical AEDs in the mouse MES model, making the combinations of BAM-IPPS with CBZ, PB, PHT and VPA neutral, from a preclinical point of view.

Keywords

EN

antiepileptic drugs; maximal electroshock-induced seizures; N-(m-bromoanilino-methyl)-p-isopropoxyphenylsuccinimide

• Publisher: De Gruyter Open
• Journal: Current Issues in Pharmacy and Medical Sciences
• Year: 2014
• Volume: 27
• Issue: 2
• Pages: 76-79

Dates

published

1 - 6 - 2014

received

12 - 3 - 2014

online

25 - 11 - 2014

accepted

8 - 4 - 2014

Contributors

author

Jarogniew J. Luszczki

• Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland
• Department of Pathophysiology, Medical University of Lublin, Ceramiczna 1, 20-150 Lublin, Poland

author

Ewa Marzeda

• Isobolographic Analysis Laboratory, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland

author

Maria W. Kondrat-Wrobel

• Department of Pathophysiology, Medical University of Lublin, Ceramiczna 1, 20-150 Lublin, Poland

author

Daniel Pyrka

• Department of Pathophysiology, Medical University of Lublin, Ceramiczna 1, 20-150 Lublin, Poland

author

Sergey L. Kocharov

• Mndjoyan’s Institute of Fine Organic Chemistry, National Academy of Sciences, Azatutyan Avenue 26, 375014 Yerevan, Republic of Armenia

author

Magdalena Florek-Luszczki

• Department of Public Health, Institute of Rural Health, Jaczewskiego 2, 20-950 Lublin, Poland

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Identifiers

DOI

10.2478/cipms-2014-0017