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2014 | 27 | 1 | 61-64
Article title

Immunomodulatory and anti-inflammatory properties of macrolides

Content
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Languages of publication
EN
Abstracts
EN
Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, to which one or more deoxy sugars may be attached. Two properties are inherent in this group of antibiotics, the immunomodulatory and the anti-inflammatory actions, ensuring great efficacy in a wide spectrum of infections. Macrolides demonstrate several immunomodulatory activities both in vitro and in vivo. They can down-regulate prolonged inflammation, increase mucus clearance, prevent the formation of bacterial biofilm and either enhance or reduce activation of the immune system. According to given properties and exceptional effects on bacterial phatogens, the macrolide antimicrobial agents have been found to serve a unique role in the management of chronic airway disorders, including diffuse panbronchiolitis, cystic fibrosis and chronic obstructive pulmonary disease. Use of macrolides can result in clinical improvement in patients with severe, chronic inflammatory airway diseases, improving their spirometry indicators, gas exchange and overall quality of life.
Publisher

Year
Volume
27
Issue
1
Pages
61-64
Physical description
Dates
published
1 - 6 - 2014
accepted
25 - 3 - 2014
received
3 - 2 - 2014
online
30 - 5 - 2014
Contributors
  • Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Muszynskiego 1, 90-151 Lodz, Poland, magdalena.bulska@umed.lodz.pl
  • Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_cipms-2014-0015
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