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2014 | 27 | 1 | 8-9
Article title

Synthesis of new derivatives of 9-(2-pyridyl)-3-aryl(arylalkyl)- -2,4,5(9H)trioxo-7,8-dihydroimidazo[1,2-a][1,3,5]triazepine

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A series of new derivatives of 9-(2-pyridyl)-3-aryl(arylalkyl)-2,4,5(9H)trioxo-7,8- dihydroimidazo [1,2-a][1,3,5] triazepine was obtained by condensation of 1-[1-(2-pyridyl) imidazolidine-2-ylidene]-3-aryl(arylalkyl)ureas) with diethyl oxalic acid ester. Considering the structure of the obtained compounds, it can be expected that these compounds can reveal pharmacological activity.
Physical description
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  • 1. Cale A; Gero T: 2-(2-subtituted aminoethyl)-1,4-dialkyl-3,4- dihydro-1H-[1,3,5]triaze-pino[3,2-a] benzimidazol-5(2H)-ones as muscle relaxants. US Patent 5 109 013.1990
  • 2. Clivio P; Peyrane F: New 1,3,5-triazepine-2,4-dione derivatives useful as antiviral and anticancer agents.e.g. for teatment of HIV infection and leucemia. US Patent 2006 4 275 057.
  • 3. Deohate P.P; Deohate Jyoti P., Berad B.N.: Novel benzo-1,3,6 triazepines:Synthesis antimicrobial activity. Asian Journal ofChemistry 16 (2), 773, 2004
  • 4. Deohate P.P; Berad B.N.: Synthesis of some novel benzo 1,3,6- thiadiazepines.Their antimicrobial activity and isomerization to benzo-1,3,5-triazepines. Oriental J Chem. 20(1), 139, 2004
  • 5. Doleschall G; Hornyak G.; Simig G. et a l: Condensed 1,3,5-triazepines-II: the synthesis of 2,3-dihydro-1H-imidazo [1,2-a] [1,3,5]benzotriazepin-5(6H)-ones and thiones.: Tetrahedron 32(1), 57, 1976[Crossref]
  • 6. Flieger J.,Czajkowska-Żelazko A.,Rządkowska M.,Szacoń E.,Matosiuk M.: Usefulness of reversed-phase HPLC enriched with room temperature imidazolium based ionic liquids for lipophilicity determination of the newly synthesized analgesic active urea derivatives. J Pharm Biomed Anal. 66, 58, 2012[WoS][Crossref]
  • 7. Hosmane RS: Ring-expanded (Fat) nucleosides as broad-spectrum anticancer and antiviral agents.; Current Topics in MedicinalChemistry 2(10), 1093, 2002
  • 8. Mahran MA, El-Sayed OA, Fahmy HT, Ashour EA: Synthesis of some novel perhydrotriazepine-3,6-diones of potential antifungal activity. J Pharm Sci. 10(2), 133, 1996
  • 9. Ruggiero D, Wiernsperger N, Paterean G, Moinet G: Preparation of triazepinones for diabetes and diabetic complications. WO Patent. 9 936 396, 1999
  • 10. Ruggiero-Lopez D, Lecomte M, Moinet G et al.: Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of advanced glycation and product formation. BiochemicalPharmacology. 58(11), 1765, 1999
  • 11. Rządkowska M, Szacoń E, Matosiuk D: Synthesis of new derivatives of 9-aryl 3-ethoxycarbonylmethyl-2,4,5(9H)trioxo-7,8- dihydroimidazo[1,2-a][1,3,5]triazepine. Curr Issues Pharm Med Sci. 26(1), 12, 2012
  • 12. Szacoń E, Rządkowska M, Matosiuk D: Synthesis of new derivatives of 1-[1-(2-pyridyl)imidazolidine-2-ylidene]-3-aryl(arylalkyl)ureas.Curr Issues Pharm Med Sci. 25(4), 499, 2012
  • 13. Szacoń E, Rządkowska M, Matosiuk D: Synthesis of new derivatives of 9-aryl-2,5(9H)-dioxo-2,3,4,5,7,8-hexahydroimidazo[1,2-a][1,3,5] triazepine. Ann. UMCS Sec. DDD 22(1), 53, 2009
  • 14. Zhang N, Chen H M, Koch V, Schmitz H et al.: Ring-expanded nucleoside and nucleoside analoques exhibit potent in vitro activity, against Flaviviridae NT Pases Helicases including those of the West Nile virus hepatitis C virus and Japanese encephalis virus. J MedChem. 46(19), 4149, 2003
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