Prioritization of the biomarkers to be analyzed in
the French biomonitoring program

• Authors: Clémence Fillol , Robert Garnier , Jean-Ulrich Mullot , Céline Boudet , Isabelle Momas , Louis Rachid Salmi , Stéphanie Vandentorren
• Languages of publication: EN

Abstracts

EN

The aim of this work was to develop a
comprehensive prioritization method to select the
biomarkers to be monitored in the French national
biomonitoring program. The first step consisted in
building an exhaustive list of biomarkers. The next step
involved prioritizing the initial list of biomarkers according
to specific scientific questions about human exposure
to chemicals in the environment, and meet logistical,
feasibility and budgetary constraints. The Delphi
consensus method was used to prioritize biomarkers and
was developed in three phases: i) the definition of relevant
criteria for selecting biomarkers; ii) the prioritization of the
biomarker list based on these criteria and iii) the validation
of the list by the stakeholders. Among the eight relevant
criteria for selecting biomarkers, hazard identification
and social perception were the highest-rated and lowestrated
criteria, respectively. After scoring each criterion
for each group of biomarkers, and discussing the relative
ranking of each group during a round table meeting, the final prioritized list obtained contained both historic (e.g.
dioxins or lead) and emerging substances (e.g. phthalates,
bisphenol A). Combining rigor and flexibility, our method
has clearly helped to build a prioritized list shared and
supported by many international actors.

Keywords

EN

Biomonitoring; Biomarkers; Environmental epidemiology; Delphi process

• Publisher: De Gruyter Open
• Journal: Biomonitoring
• Year: 2014
• Volume: 1
• Issue: 1

Dates

received

13 - 8 - 2014

accepted

16 - 10 - 2014

online

29 - 10 - 2014

Contributors

author

Clémence Fillol

• Institut de veille sanitaire, Département Santé environnement,
  12 rue du Val d’Osne, 94415 Saint Maurice, France

author

Robert Garnier

• Paris poison center. Hôpitaux universitaires Saint-
  Louis-Lariboisière-Fernand Widal, AP-HP & Université Paris-Diderot,
  Paris, France

author

Jean-Ulrich Mullot

• Laboratoire d’Analyses de Surveillance et
  d’Expertise de la Marine, 83000 Toulon, France

author

Céline Boudet

• Institut National de l’Environnement Industriel et des
  Risques, (INERIS), 60 550 Verneuil en Halatte, France

author

Isabelle Momas

• Université Paris Descartes, Laboratoire Santé
  Publique et Environnement – EA 4064, Paris, France

author

Louis Rachid Salmi

• Univ. Bordeaux, ISPED, Centre INSERM U897-
  Epidemiologie-Biostatistique, F-33000 Bordeaux, France
• INSERM, ISPED, Centre INSERM U897-Epidemiologie-
  Biostatistique, F-33000 Bordeaux, France
• CHU de Bordeaux, Pole de sante publique,
  Service d’information medicale, F-33000 Bordeaux, France

author

Stéphanie Vandentorren

• Institut de veille sanitaire, Département Santé environnement,
  12 rue du Val d’Osne, 94415 Saint Maurice, France

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Identifiers

DOI

10.2478/bimo-2014-0010