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Article title

The association between use of sunscreens and
cosmetics and urinary concentrations of the UV
filter ethylhexyl-methoxy cinnamate: A pilot
biomonitoring study

Title variants
Languages of publication
Ethylhexyl-methoxy cinnamate (EHMC), an
ultraviolet (UV) filter that absorbs solar UVB radiation
is frequently used in the formulation of sunscreens and
cosmetics. Except for the controlled UV filter application
studies, no general population studies on the magnitude
and variability of exposures to EHMC exist. Given the
widespread use of UV filters in consumer products, a
pilot human biomonitoring study was undertaken to: i)
determine the concentrations of EHMC in urine samples of
young adults, and ii) investigate the association between
consumption patterns of selected consumer products and
urinary EHMC concentrations. A group of 48 randomlyselected
volunteers provided a first morning urine void
and a questionnaire on the types and usage patterns of
sunscreens and cosmetics was administered to them.
Significantly (p=0.006) higher urinary EHMC levels were
observed in females, and in users of face sunscreens
(p=0.008) and lipsticks (p=0.003). Linear multiple
regression analysis showed that the frequency of use of
face sunscreens (all year) (p=0.02) and gender (females)
(p=0.03) were significant predictors of creatinine-adjusted
urinary EHMC levels in the pooled sample, even after
adjusting for relevant covariates, such as age, body-mass
index and the number of cosmetics used. A larger sample
could help us further evaluate the observed trends.
Physical description
17 - 8 - 2014
26 - 9 - 2014
7 - 11 - 2014
  • [1] Lomas A., Leonardi-Bee J., Bath-Hextall F., A systematic reviewof worldwide incidence of nonmelanoma skin cancer, Br. J.Dermatol., 2012,166, 1069–80.[WoS]
  • [2] Palm M.D., O’Donoghue MN. Update on photoprotection,Dermatol. Ther., 2007, 20, 360–76.
  • [3] Giokas D.L., Salvador A., Chisvert A., UV filters: Fromsunscreens to human body and the environment, TrAC TrendsAnal. Chem.. 2007, 26, 360–74.[WoS]
  • [4] Krause M., Klit A Blomberg Jensen, M., Søeborg, T.,Frederiksen, H., Schlumpf, M., Lichtensteiger, W., Skakkebaek,N.E., Drzewiecki, K.T., Sunscreens: are they beneficial forhealth? An overview of endocrine disrupting properties ofUV-filters, Int. J. Androl., 2012, 35, 424–36.[WoS]
  • [5] Schlumpf M., Cotton B., Conscience M., Haller V., SteinmannB., Lichtensteiger W., In vitro and in vivo estrogenicity of UVscreens, Environ. Health Perspect., 2001, 109, 239-243.
  • [6] List of UV filters allowed in cosmetic products [Internet].European Commission - Health and Consumers, ScientificCommittees. 2014 [cited 2014 Jul 29]. Available from:
  • [7] Opinion on the Evaluation of Potentially Estrogenic Effectsof UV-filters adopted by the SCCNFP during the 17th Plenarymeeting of 12 June 2001 [Internet]. European Commission- Health and Consumers, Scientific Committees. [cited2014 Jul 29]. Available from:
  • [8] CFR - Code of Federal Regulations Title 21 [Internet]. U.S. Foodand Drug Administration. 2013 [cited 2014 Jul 29]. Availablefrom:
  • [9] Manová E., von Goetz N., Hauri U., Bogdal C., Hungerbühler K.,Organic UV filters in personal care products in Switzerland: asurvey of occurrence and concentrations, Int. J. Hyg. Environ.Health., 2013, 216, 508–514.[WoS]
  • [10] Miranda M.S., Pinto da Silva L., Esteves da Silva J.C.G., UV filter2-ethylhexyl 4-methoxycinnamate: a structure, energetic andUV–vis spectral analysis based on density functional theory, J.Phys. Org. Chem., 2014, 27, 47–56.
  • [11] Moloney F.J., Collins S., Murphy G.M., Sunscreens: safety,efficacy and appropriate use. Am. J. Clin. Dermatol., 2002,185–191.[Crossref]
  • [12] Petersen G., Rasmussen D., Gustavson K., Study onenhancing the Endocrine Disrupter priority list with focuson low production volume chemicals [Internet]. DHI Water& Environment; 2007. Available from:
  • [13] Heneweer M., Muusse M., Berg M. van den, Sanderson J.T.,Additive estrogenic effects of mixtures of frequently used UVfilters on pS2-gene transcription in MCF-7 cells, Toxicol. Appl.Pharmacol., 2005, 208, 170–177.
  • [14] Axelstad M., Boberg, J., Hougaard, K.S., Christiansen, S.,Jacobsen, P.R., Mandrup, K.R., Nellemann, C., Lund, S.P.,Hass, U., Effects of pre- and postnatal exposure to the UV-filterOctyl Methoxycinnamate (OMC) on the reproductive, auditoryand neurological development of rat offspring. Toxicol ApplPharmacol., 2011, 250, 278–90.
  • [15] Schneider S., Deckardt, K., Hellwig, J., Küttler, K., Mellert, W.,Schulte, S., van Ravenzwaay, B., Octyl methoxycinnamate:Two generation reproduction toxicity in Wistar rats by dietaryadministration, Food Chem. Toxicol., 2005, 43, 1083–1092.
  • [16] Janjua N., Kongshoj B., Andersson A.M., Wulf H., Sunscreensin human plasma and urine after repeated whole-body topicalapplication, J. Eur. Acad. Dermatol. Venereol., 2008, 22,456–461.[WoS][Crossref]
  • [17] Janjua, N.R., Mogensen, B., Andersson, A.-M., Petersen,J.H., Henriksen, M., Skakkebæk, N.E., Wulf, H.C., SystemicAbsorption of the Sunscreens Benzophenone-3, Octyl-Methoxycinnamate,and 3-(4-Methyl-Benzylidene) Camphor AfterWhole-Body Topical Application and Reproductive HormoneLevels in Humans, J. Invest. Dermatol., 2004, 123, 57–61.
  • [18] Schlumpf M., Kypke, K., Wittassek, M., Angerer, J., Mascher, H.,Mascher, D., Vökt, C., Birchler, M., Lichtensteiger, W., Exposurepatterns of UV filters, fragrances, parabens, phthalates,organochlor pesticides, PBDEs, and PCBs in human milk:Correlation of UV filters with use of cosmetics. Chemosphere,2010, 81, 1171–1183.[WoS]
  • [19] March J.G., Genestar C., Simonet B.M., Determinationof 2-ethylhexyl 4-(dimethylamino) benzoate usingmembrane-assisted liquid–liquid extraction and gas chromatography-mass spectrometric detection. Anal. Bioanal. Chem.,2009, 394, 883–91.
  • [20] Li, B., Hartono, C., Ding, R., Sharma, V.K., Ramaswamy, R.,Qian, B., Serur, D., Mouradian, J., Schwartz, J.E., Suthanthiran,M., Noninvasive Diagnosis of Renal-Allograft Rejection byMeasurement of Messenger RNA for Perforin and Granzyme Bin Urine, N. Engl. J. Med., 2001, 344, 947–954.
  • [21] R. Core Team. R: A language and environment for statisticalcomputing [Internet]. Vienna, Austria: R Foundation forStatistical Computing; 2013. Available from:
  • [22] Wickham H. ggplot2: elegant graphics for data analysis[Internet]. Springer New York; 2009. Available from:
  • [23] MSC (Meteorological Service of Cyprus). Ministry of Agriculture,Environ. and Nat. Resources, Nicosia [Internet]. [cited 2014Sep 4]. Available from:$file/MAX%20-%20MIN%20-%20RAIN_08_2010.pdf?Openelement
  • [24] Nash J.F., Tanner P.R., Relevance of UV filter/sunscreen productphotostability to human safety. Photodermatol. Photoimmunol.Photomed., 2014, 30, 88–95.
  • [25] Benson H.A., Sarveiya V., Risk S., Roberts M.S., Influence ofanatomical site and topical formulation on skin penetration ofsunscreens. Ther. Clin. Risk Manag., 2005, 1, 209–18.
  • [26] Jiménez M.M., Pelletier J., Bobin M.F., Martini M.C., Influence ofencapsulation on the in vitro percutaneous absorption of octylmethoxycinnamate, Int. J. Pharm., 2004, 272, 45–55.
  • [27] Yener G., Incegül T., Yener N., Importance of using solid lipidmicrospheres as carriers for UV filters on the example octylmethoxy cinnamate, Int. J. Pharm., 2003, 258, 203–7.
  • [28] Vilela F.M.P., Fonseca Y.M., Jabor J.R., Vicentini F.T.M.C.,Fonseca M.J.V., Effect of ultraviolet filters on skin superoxidedismutase activity in hairless mice after a single dose ofultraviolet radiation, Eur. J. Pharm. Biopharm., 2012, 80,387–92.[WoS]
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