PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2014 | 1 | 1 |
Article title

The influence of perinatal and current dioxin and PCB exposure on puberty: a review

Content
Title variants
Languages of publication
EN
Abstracts
EN
Over the last two decades much has been
written about the consequences of perinatal dioxin
and PCB exposure in humans. In this paper we strive
to elucidate the data on puberty in relation to these
endocrine disruptive compounds in human populations.
Effects in PCB/dioxin-exposed human populations on
puberty are seen, not only in highly exposed cohorts, but
also in average populations with background exposures.
Study showed effects like increased weight, a delay
in pubic hair growth and male genital development in
boys, sex-hormone homeostasis, reduced penile length,
and delayed age at first ejaculation after PCB exposure.
Effects seen after dioxin exposure include retarded
initiation and stage of breast development in girls, earlier
menarche, disruption of sex hormone homeostasis,
reduced testicular volume and reduced penile length
in boys. The data published by different studies were
inconclusive as a result of different methodological
setup as well as because of multiple exposure settings.
Populations were exposed to different mixtures of
dioxin/PCB congeners or mixtures with other endocrine
disrupters, and therefore synergistic and antagonistic
effects with PCBs and dioxins are possible. Dioxinlike
compounds disturb the hormonal balance mainly through interaction with the Ah receptor, which may
influence the synthesis of hormones or their transport
proteins. However, we have to keep in mind that
hormonal balance during puberty could also be altered
by disruption of the thyroid homeostasis. Another
important possible mechanism is the induction of
epigenetic changes or effects on genetic polymorphism.
The fact that exposure to background concentrations of
dioxin-like compounds and PCBs also has effects on the
reproductive development is disconcerting and warrants
further research and long term follow-up studies.
Publisher
Journal
Year
Volume
1
Issue
1
Physical description
Dates
accepted
15 - 4 - 2014
received
23 - 2 - 2014
online
9 - 6 - 2014
References
  • [1] Pirkle, J. L.; Wolfe, W. H.; Patterson, D. G.; Needham, L. L.;Michalek, J. E.; Miner, J. C.; Peterson, M. R.; and Phillips, D.L. Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand. J. Toxicol.Environ. Health. 1989, 27 (2), 165-171.[Crossref]
  • [2] Nelson, J. A. Effects of dichlorodiphenyltrichloroethane (DDT)analogs and polychlorinated biphenyl (PCB) mixtures on17beta-(3H)estradiol binding to rat uterine receptor. Biochem.Pharmacol. 1974, 23 (2), 447-451.[Crossref]
  • [3] Hansen, L. G. Stepping backward to improve assessment ofPCB congener toxicities. Environ. Health Perspect. 1998, 106Suppl 1 171-189.
  • [4] Leijs, M. M.; Ten Tusscher, G. W.; Olie, K.; van, T. T.; vanAalderen, W. M.; de, V. P.; Vulsma, T.; Bartonova, A.; Krayer von,K. M.; Mosoiu, C.; Riojas-Rodriguez, H.; Calamandrei, G.; andKoppe, J. G. Thyroid hormone metabolism and environmentalchemical exposure. Environ. Health. 2012, 11 Suppl 1 S10-[Crossref]
  • [5] Lundqvist, C.; Zuurbier, M.; Leijs, M.; Johansson, C.; Ceccatelli,S.; Saunders, M.; Schoeters, G.; ten, T. G.; and Koppe, J. G.The effects of PCBs and dioxins on child health. Acta Paediatr.Suppl. 2006, 95 (453), 55-64.
  • [6] Khan, M. A. and Hansen, L. G. Ortho-substituted polychlorinatedbiphenyl (PCB) congeners (95 or 101) decrease pituitaryresponse to thyrotropin releasing hormone. Toxicol. Lett. 2003,144 (2), 173-182.[Crossref]
  • [7] Koppe, J. G. Dioxins and furans in the mother and possibleeffects on the fetus and newborn breast-fed baby. ActaPaediatr. Scand. Suppl. 1989, 360 146-153.
  • [8] Koppe, J. G. Nutrition and breast-feeding. Eur. J. Obstet.Gynecol. Reprod. Biol. 1995, 61 (1), 73-78.[Crossref]
  • [9] Grimalt, J. O.; Howsam, M.; Carrizo, D.; Otero, R.; de Marchi,M. R.; and Vizcaino, E. Integrated analysis of halogenatedorganic pollutants in sub-millilitre volumes of venous andumbilical cord blood sera. Anal. Bioanal. Chem. 2010, 396 (6),2265-2272.[WoS]
  • [10] van den Berg, M.; van der Wielen, F. W. M.; Olie, K.; and vanBoxtel, C. J. The presence of PCDDs and PCDFs in humanbreastmilk from The Netherlands. Chemosphere. 1986, 15693-706.[Crossref]
  • [11] World Health Organisation Levels of PCBs, PCDDs and PCDFs inbreast milk. WHO, 1989.
  • [12] World Health Organisation Levels of PCBs, PCDDs and PCDFs inhuman milk. WHO, 1996.[PubMed]
  • [13] Rappe, C.; Nygren, M.; Lindström, G.; and Hansson, M. Dioxinsand dibenzofurans in blood and adipose tissue of Europeanorigin. Chemosphere. 1986, 15 1635-1639.[Crossref]
  • [14] Goldman, L. R. Chemicals and children‘s environment: what wedon‘t know about risks. Environ. Health Perspect. 1998, 106Suppl 3 875-880.
  • [15] Howdeshell, K. L.; Hotchkiss, A. K.; Thayer, K. A.; Vandenbergh,J. G.; and vom Saal, F. S. Exposure to bisphenol A advancespuberty. Nature. 1999, 401 (6755), 763-764.
  • [16] Gray, L. E., Jr. and Ostby, J. S. In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology andfunction in female rat offspring. Toxicol. Appl. Pharmacol. 1995,133 (2), 285-294.
  • [17] Sager, D. B. and Girard, D. M. Long-term effects on reproductiveparameters in female rats after translactational exposure toPCBs. Environ. Res. 1994, 66 (1), 52-76.[Crossref]
  • [18] Fenton, S. E.; Hamm, J. T.; Birnbaum, L. S.; and Youngblood, G.L. Persistent abnormalities in the rat mammary gland followinggestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Sci. 2002, 67 (1), 63-74.[Crossref]
  • [19] Rogan, W. J.; Gladen, B. C.; Hung, K. L.; Koong, S. L.; Shih, L.Y.; Taylor, J. S.; Wu, Y. C.; Yang, D.; Ragan, N. B.; and Hsu, C. C.Congenital poisoning by polychlorinated biphenyls and theircontaminants in Taiwan. Science. 1988, 241 (4863), 334-336.
  • [20] ten Tusscher, G. W.; de, W. J.; Roos, C. M.; Griffioen, R. W.; DeJongh, F. H.; Westra, M.; van der Slikke, J. W.; Oosting, J.; Olie,K.; and Koppe, J. G. Decreased lung function associated withperinatal exposure to Dutch background levels of dioxins. ActaPaediatr. 2001, 90 (11), 1292-1298.
  • [21] Pluim, H. J.; Koppe, J. G.; Olie, K.; van der Slikke, J. W.; Slot,P. C.; and van Boxtel, C. J. Clinical laboratory manifestationsof exposure to background levels of dioxins in the perinatalperiod. Acta Paediatr. 1994, 83 (6), 583-587.
  • [22] Weisglas-Kuperus, N.; Sas, T. C.; Koopman-Esseboom, C.; vander Zwan, C. W.; De Ridder, M. A.; Beishuizen, A.; Hooijkaas,H.; and Sauer, P. J. Immunologic effects of background prenataland postnatal exposure to dioxins and polychlorinatedbiphenyls in Dutch infants. Pediatr. Res. 1995, 38 (3), 404-410.[Crossref]
  • [23] ten Tusscher, G. W.; Steerenberg, P. A.; van Loveren, H.; Vos,J. G.; dem Borne, A. E.; Westra, M.; van der Slikke, J. W.;Olie, K.; Pluim, H. J.; and Koppe, J. G. Persistent hematologicand immunologic disturbances in 8-year-old Dutch childrenassociated with perinatal dioxin exposure. Environ. HealthPerspect. 2003, 111 (12), 1519-1523.[Crossref]
  • [24] Leijs, M. M.; Koppe, J. G.; Olie, K.; van Aalderen, W. M.; de, V.P.; and ten Tusscher, G. W. Effects of dioxins, PCBs, and PBDEson immunology and hematology in adolescents. Environ. Sci.Technol. 2009, 43 (20), 7946-7951.[Crossref][WoS]
  • [25] Ten Tusscher, G. W.; Leijs, M. M.; de Boer, L. C.; Legler, J.; Olie,K.; Spekreijse, H.; van Dijk, B. W.; Vulsma, T.; Briet, J.; Ilsen, A.;and Koppe, J. G. Neurodevelopmental retardation, as assessedclinically and with magnetoencephalography and electroencephalography,associated with perinatal dioxin exposure. Sci.Total Environ. 2014, Mar 19. pii: S0048-9697(14)00283-6. doi:10.1016/j.scitotenv.2014.02.100. [Epub ahead of print][Crossref][WoS]
  • [26] Gladen, B. C.; Ragan, N. B.; and Rogan, W. J. Pubertal growthand development and prenatal and lactational exposureto polychlorinated biphenyls and dichlorodiphenyl dichloroethene.J. Pediatr. 2000, 136 (4), 490-496.
  • [27] Den Hond, E.; Roels, H. A.; Hoppenbrouwers, K.; Nawrot, T.;Thijs, L.; Vandermeulen, C.; Winneke, G.; Vanderschueren, D.;and Staessen, J. A. Sexual maturation in relation to polychlorinatedaromatic hydrocarbons: Sharpe and Skakkebaek‘shypothesis revisited. Environ. Health Perspect. 2002, 110 (8),771-776.[Crossref]
  • [28] Leijs, M. M.; Koppe, J. G.; Olie, K.; van Aalderen, W. M.; Voogt,P.; Vulsma, T.; Westra, M.; and ten Tusscher, G. W. Delayedinitiation of breast development in girls with higher prenataldioxin exposure; a longitudinal cohort study. Chemosphere.2008, 73 (6), 999-1004.[WoS][Crossref]
  • [29] Fries, G. F. The PBB episode in Michigan: an overall appraisal.Crit Rev. Toxicol. 1985, 16 (2), 105-156.[Crossref]
  • [30] Blanck, H. M.; Marcus, M.; Tolbert, P. E.; Rubin, C.; Henderson,A. K.; Hertzberg, V. S.; Zhang, R. H.; and Cameron, L. Ageat menarche and tanner stage in girls exposed in utero andpostnatally to polybrominated biphenyl. Epidemiology. 2000,11 (6), 641-647.[Crossref]
  • [31] Vasiliu, O.; Muttineni, J.; and Karmaus, W. In utero exposure toorganochlorines and age at menarche. Hum. Reprod. 2004, 19(7), 1506-1512.[Crossref]
  • [32] Warner, M.; Samuels, S.; Mocarelli, P.; Gerthoux, P. M.;Needham, L.; Patterson, D. G., Jr.; and Eskenazi, B. Serumdioxin concentrations and age at menarche. Environ. HealthPerspect. 2004, 112 (13), 1289-1292.[Crossref]
  • [33] Wolff, M. S.; Britton, J. A.; and Russo, J. C. TCDD and puberty ingirls. Environ. Health Perspect. 2005, 113 (1), A17-[Crossref]
  • [34] Hsu, P. C.; Lai, T. J.; Guo, N. W.; Lambert, G. H.; and Leon, G. Y.Serum hormones in boys prenatally exposed to polychlorinatedbiphenyls and dibenzofurans. J. Toxicol. Environ. Health A.2005, 68 (17-18), 1447-1456.[Crossref]
  • [35] Richthoff, J.; Rylander, L.; Jonsson, B. A.; Akesson, H.; Hagmar,L.; Nilsson-Ehle, P.; Stridsberg, M.; and Giwercman, A. Serumlevels of 2,2‘,4,4‘,5,5‘-hexachlorobiphenyl (CB-153) in relationto markers of reproductive function in young males from thegeneral Swedish population. Environ. Health Perspect. 2003,111 (4), 409-413.
  • [36] Henriksen, G. L. and Michalek, J. E. Serum dioxin, testosterone,and gonadotropins in veterans of Operation Ranch Hand.Epidemiology. 1996, 7 (4), 454-455.
  • [37] Henriksen, G. L.; Michalek, J. E.; Swaby, J. A.; and Rahe, A. J.Serum dioxin, testosterone, and gonadotropins in veterans ofOperation Ranch Hand. Epidemiology. 1996, 7 (4), 352-357.[Crossref]
  • [38] Korrick, S. A.; Lee, M. M.; Williams, P. L.; Sergeyev, O.; Burns,J. S.; Patterson, D. G.; Turner, W. E.; Needham, L. L.; Altshul, L.;Revich, B.; and Hauser, R. Dioxin exposure and age of pubertalonset among Russian boys. Environ. Health Perspect. 2011, 119(9), 1339-1344.[WoS]
  • [39] Humblet, O.; Williams, P. L.; Korrick, S. A.; Sergeyev, O.; Emond,C.; Birnbaum, L. S.; Burns, J. S.; Altshul, L.; Patterson, D. G., Jr.;Turner, W. E.; Lee, M. M.; Revich, B.; and Hauser, R. Dioxin andpolychlorinated biphenyl concentrations in mother‘s serum andthe timing of pubertal onset in sons. Epidemiology. 2011, 22(6), 827-835.[Crossref][WoS]
  • [40] Grandjean, P.; Gronlund, C.; Kjaer, I. M.; Jensen, T. K.;Sorensen, N.; Andersson, A. M.; Juul, A.; Skakkebaek, N. E.;Budtz-Jorgensen, E.; and Weihe, P. Reproductive hormoneprofile and pubertal development in 14-year-old boys prenatallyexposed to polychlorinated biphenyls. Reprod. Toxicol. 2012,34 (4), 498-503.[Crossref]
  • [41] Guo, Y. L.; Lambert, G. H.; Hsu, C. C.; and Hsu, M. M. Yucheng:health effects of prenatal exposure to polychlorinatedbiphenyls and dibenzofurans. Int. Arch. Occup. Environ. Health.2004, 77 (3), 153-158.[Crossref]
  • [42] Rogan, W. J. and Ragan, N. B. Evidence of effects ofenvironmental chemicals on the endocrine system in children.Pediatrics. 2003, 112 (1 Pt 2), 247-252.
  • [43] Hushka, L. J.; Williams, J. S.; and Greenlee, W. F. Characterizationof 2,3,7,8-tetrachlorodibenzofuran-dependentsuppression and AH receptor pathway gene expression in thedeveloping mouse mammary gland. Toxicol. Appl. Pharmacol.1998, 152 (1), 200-210.[Crossref]
  • [44] Schoeters, G.; Den, H. E.; Dhooge, W.; van, L. N.; and Leijs,M. Endocrine disruptors and abnormalities of pubertaldevelopment. Basic Clin Pharmacol. Toxicol. 2008, 102 (2),168-175.[Crossref][WoS]
  • [45] Buck Louis, G. M.; Gray, L. E., Jr.; Marcus, M.; Ojeda, S. R.;Pescovitz, O. H.; Witchel, S. F.; Sippell, W.; Abbott, D. H.; Soto,A.; Tyl, R. W.; Bourguignon, J. P.; Skakkebaek, N. E.; Swan,S. H.; Golub, M. S.; Wabitsch, M.; Toppari, J.; and Euling, S.Y. Environmental factors and puberty timing: expert panelresearch needs. Pediatrics. 2008, 121 Suppl 3 S192-S207.[WoS]
  • [46] Arlt, W.; Martens, J. W.; Song, M.; Wang, J. T.; Auchus, R. J.;and Miller, W. L. Molecular evolution of adrenarche: structuraland functional analysis of p450c17 from four primate species.Endocrinology. 2002, 143 (12), 4665-4672.
  • [47] Saurat, J. H.; Kaya, G.; Saxer-Sekulic, N.; Pardo, B.; Becker, M.;Fontao, L.; Mottu, F.; Carraux, P.; Pham, X. C.; Barde, C.; Fontao,F.; Zennegg, M.; Schmid, P.; Schaad, O.; Descombes, P.; andSorg, O. The cutaneous lesions of dioxin exposure: lessonsfrom the poisoning of Victor Yushchenko. Toxicol. Sci. 2012, 125(1), 310-317.[WoS][Crossref]
  • [48] Ghosh, S.; Zang, S.; Mitra, P. S.; Ghimbovschi, S.; Hoffman,E. P.; and Dutta, S. K. Global gene expression and Ingenuitybiological functions analysis on PCBs 153 and 138 inducedhuman PBMC in vitro reveals differential mode(s) of action indeveloping toxicities. Environ. Int. 2011, 37 (5), 838-857.[WoS]
  • [49] Casati, L.; Sendra, R.; Poletti, A.; Negri-Cesi, P.; and Celotti, F.Androgen receptor activation by polychlorinated biphenyls:epigenetic effects mediated by the histone demethylaseJarid1b. Epigenetics. 2013, 8 (10), 1061-1068.[WoS][Crossref]
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_bimo-2014-0002
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.