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2014 | 1 | 1 |

Article title

The influence of perinatal and current dioxin and PCB exposure on reproductive parameters (sex-ratio, menstrual cycle characteristics, endometriosis, semen quality, and prematurity): a review

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EN

Abstracts

EN
Polychlorinated biphenyls (PCBs) and dioxins
(PCDDs/Fs) are well-known endocrine disrupters. This
paper strives to elucidate the data on reproductive
consequences of perinatal dioxin and PCB exposure in
men and women. We focused on the following end-points:
sex-ratio, endometriosis, menstrual cycle characteristics,
sperm quality, and prematurity. We summarize 46 papers
and compare their results including effects seen after
exposure to background concentrations. Seven of twelve
studies showed a decrease in sex-ratio after parental dioxin
or PCB exposure. In three of the seven studies, effects were
seen after paternal exposure and in three after maternal
exposure. In eight of the nine studies on menstrual cycle
characteristics, abnormalities were associated with
PCB or dioxin exposure, however the results differed. In
three studies PCB and TCDD were associated with longer
menstrual cycles, while three studies indicated that an
increase in PCB/PCDF exposure was associated with
shorter cycles. Five studies showed effects on menstrual
bleeding with higher PCB or dioxin exposure. A higher rate of irregular menstrual cycles in exposed women was
seen in four studies. The conflicting outcomes probably
result from variability in study design, timing of exposure
and endocrine disrupting properties of the measured
congeners. Nine of sixteen studies detected higher PCB or
dioxin exposure in women with endometriosis. However,
the manner of diagnosing endometriosis and the character
of the studies varied from prospective to retrospective. Five
of eight studies focusing on sperm quality showed that
men, with higher serum concentrations of PCBs and/or
PCB congeners and/or PCDFs, had reduced sperm quality,
including increased abnormal morphology and reduced
motility. The exposure timeframe seemed important here.
There are two studies addressing preterm birth in relation
to PCBs, one mentioned a shortening of three days of
gestational age, two other studies did not find a relation.
Recently one study related a shorter gestational age of
half a week with overall dioxin activity measured with
the CALUX method in cord blood, particularly in boys. In
conclusion, exposure to PCBs and dioxins has a negative
effect on the reproductive systems of human populations.
Although some speculations have been made, the exact
mechanism of these effects and the interactions of these
compounds with other endocrine disruptors are not yet
known. Age at exposure and congener specific properties
are probably crucial in interpreting the observed results.

Publisher

Journal

Year

Volume

1

Issue

1

Physical description

Dates

received
10 - 2 - 2014
accepted
10 - 4 - 2014
online
9 - 6 - 2014

Contributors

author
  • Department of Paediatrics and Neonatology, Emma Children’s Hospital,
    Academic Medical Centre, Amsterdam, PO Box 22660 1100DD
    Amsterdam, The Netherlands
  • Institute for Biodiversity and Ecosystem Dynamics,
    IBED, University of Amsterdam, Sciencepark 904, 1098 XH
    Amsterdam, The Netherlands
  • Department of Dermatology, RWTH University Hospital
    Aachen, Pauwelstrasse 30, 52074 Aachen, Germany
  • Institute for Biodiversity and Ecosystem Dynamics,
    IBED, University of Amsterdam, Sciencepark 904, 1098 XH
    Amsterdam, The Netherlands
author
  • Department of Paediatrics and Neonatology, Emma Children’s Hospital,
    Academic Medical Centre, Amsterdam, PO Box 22660 1100DD
    Amsterdam, The Netherlands
  • Ecobaby Foundation, Hollandstraat 6 3634 AT Loenersloot,
    The Netherlands, Fax: 31-294-291373
author
  • Institute for Biodiversity and Ecosystem Dynamics,
    IBED, University of Amsterdam, Sciencepark 904, 1098 XH
    Amsterdam, The Netherlands
  • Department of Paediatrics and Neonatology, Emma Children’s Hospital,
    Academic Medical Centre, Amsterdam, PO Box 22660 1100DD
    Amsterdam, The Netherlands
  • Department of Paediatrics and Neonatology, Westfriesgasthuis,
    Maelsonstraat 3, 1624 NP Hoorn, The Netherlands

References

  • [1] Brouwer, A.; Longnecker, M. P.; Birnbaum, L. S.; Cogliano, J.;Kostyniak, P.; Moore, J.; Schantz, S.; and Winneke, G. Characterizationof potential endocrine-related health effects atlow-dose levels of exposure to PCBs. Environ. Health Perspect.1999, 107 Suppl 4 639-649.
  • [2] Gore, A. C.; Wu, T. J.; Oung, T.; Lee, J. B.; and Woller, M. J. Anovel mechanism for endocrine-disrupting effects of polychlorinated biphenyls: direct effects on gonadotropin-releasinghormone neurones. J. Neuroendocrinol. 2002, 14 (10), 814-823.[Crossref]
  • [3] Hsu, S. T.; Ma, C. I.; Hsu, S. K.; Wu, S. S.; Hsu, N. H.; Yeh, C. C.;and Wu, S. B. Discovery and epidemiology of PCB poisoning inTaiwan: a four-year followup. Environ. Health Perspect. 1985,59 5-10.[Crossref]
  • [4] Yoshimura, T. Yusho in Japan. Ind. Health. 2003, 41 (3),139-148.[Crossref]
  • [5] Chen, Y. C.; Guo, Y. L.; Hsu, C. C.; and Rogan, W. J. Cognitivedevelopment of Yu-Cheng (“oil disease”) children prenatallyexposed to heat-degraded PCBs. JAMA. 1992, 268 (22),3213-3218.
  • [6] Rogan, W. J.; Gladen, B. C.; Hung, K. L.; Koong, S. L.; Shih, L.Y.; Taylor, J. S.; Wu, Y. C.; Yang, D.; Ragan, N. B.; and Hsu, C. C.Congenital poisoning by polychlorinated biphenyls and theircontaminants in Taiwan. Science. 1988, 241 (4863), 334-336.
  • [7] Bertazzi, P.A. and Domenico, A. Dioxins and health. John Wiley& Sons. 2003. 827-853.
  • [8] Eskenazi, B.; Mocarelli, P.; Warner, M.; Samuels, S.; Vercellini,P.; Olive, D.; Needham, L.; Patterson, D.; and Brambilla,P. Seveso Women’s Health Study: a study of the effects of2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive health.Chemosphere. 2000, 40 (9-11), 1247-1253.[Crossref]
  • [9] Stellman, S. D.; Stellman, J. M.; and Sommer, J. F., Jr. Healthand reproductive outcomes among American Legionnaires inrelation to combat and herbicide exposure in Vietnam. Environ.Res. 1988, 47 (2), 150-74.[Crossref]
  • [10] Roby, K. F. Mechanism of TCDD-mediated inhibition ofovulation. Biol Reprod. 2000, 62 (Suppl) 284-284.
  • [11] Li, X.; Johnson, D. C.; and Rozman, K. K. Reproductive effectsof 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female rats:ovulation, hormonal regulation, and possible mechanism(s).Toxicol. Appl. Pharmacol. 1995, 133 (2), 321-327.[Crossref]
  • [12] Rier, S. E.; Martin, D. C.; Bowman, R. E.; Dmowski, W. P.;and Becker, J. L. Endometriosis in rhesus monkeys (Macacamulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam. Appl. Toxicol. 1993, 21 (4), 433-441.[Crossref]
  • [13] Olive, D. L. and Schwartz, L. B. Endometriosis. N. Engl. J. Med.1993, 328 (24), 1759-1769.[Crossref]
  • [14] Graffelman, J.; Fugger, E. F.; Keyvanfar, K.; and Schulman, J. D.Human live birth and sperm-sex ratios compared. Hum. Reprod.1999, 14 (11), 2917-2920.[PubMed][Crossref]
  • [15] Yoshimura, T.; Kaneko, S.; and Hayabuchi, H. Sex ratioin offspring of those affected by dioxin and dioxin-likecompounds: the Yusho, Seveso, and Yucheng incidents. Occup.Environ. Med. 2001, 58 (8), 540-541.[Crossref]
  • [16] Mocarelli, P.; Brambilla, P.; Gerthoux, P. M.; Patterson, D. G., Jr.;and Needham, L. L. Change in sex ratio with exposure to dioxin.Lancet. 1996, 348 (9024), 409-
  • [17] Mocarelli, P.; Gerthoux, P. M.; Ferrari, E.; Patterson, D. G.,Jr.; Kieszak, S. M.; Brambilla, P.; Vincoli, N.; Signorini, S.;Tramacere, P.; Carreri, V.; Sampson, E. J.; Turner, W. E.; andNeedham, L. L. Paternal concentrations of dioxin and sex ratioof offspring. Lancet. 2000, 355 (9218), 1858-1863.
  • [18] Rogan, W. J.; Gladen, B. C.; Guo, Y. L.; and Hsu, C. C. Sex ratioafter exposure to dioxin-like chemicals in Taiwan. Lancet. 1999,353 (9148), 206-207.
  • [19] Del, Rio-Gomez., I; Marshall, T.; Tsai, P.; Shao, Y. S.; and Guo,Y. L. Number of boys born to men exposed to polychlorinatedbyphenyls. Lancet. 2002, 360 (9327), 143-144.
  • [20] Ryan, J. J.; Amirova, Z.; and Carrier, G. Sex ratios of children ofRussian pesticide producers exposed to dioxin. Environ. HealthPerspect. 2002, 110 (11), A699-A701.[Crossref]
  • [21] Weisskopf, M. G.; Anderson, H. A.; and Hanrahan, L. P.Decreased sex ratio following maternal exposure to polychlorinatedbiphenyls from contaminated Great Lakes sport-caughtfish: a retrospective cohort study. Environ. Health. 2003, 2 (1),2-[Crossref]
  • [22] Karmaus, W.; Huang, S.; and Cameron, L. Parental concentrationof dichlorodiphenyl dichloroethene and polychlorinatedbiphenyls in Michigan fish eaters and sex ratio in offspring. J.Occup. Environ. Med. 2002, 44 (1), 8-13.
  • [23] Hertz-Picciotto, I.; Jusko, T. A.; Willman, E. J.; Baker, R. J.;Keller, J. A.; Teplin, S. W.; and Charles, M. J. A cohort study of inutero polychlorinated biphenyl (PCB) exposures in relation tosecondary sex ratio. Environ. Health. 2008, 7 37-[Crossref]
  • [24] Schnorr, T. M.; Lawson, C. C.; Whelan, E. A.; Dankovic, D. A.;Deddens, J. A.; Piacitelli, L. A.; Reefhuis, J.; Sweeney, M. H.;Connally, L. B.; and Fingerhut, M. A. Spontaneous abortion, sexratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ. Health Perspect. 2001, 109 (11),1127-1132.[Crossref]
  • [25] Taylor, K. C.; Jackson, L. W.; Lynch, C. D.; Kostyniak, P. J.; andBuck Louis, G. M. Preconception maternal polychlorinatedbiphenyl concentrations and the secondary sex ratio. Environ.Res. 2007, 103 (1), 99-105.[Crossref]
  • [26] Khanjani, N. and Sim, M. R. Maternal contamination with PCBsand reproductive outcomes in an Australian population. J.Expo. Sci. Environ. Epidemiol. 2007, 17 (2), 191-195.[Crossref]
  • [27] Rogan, W. J. and Ragan, N. B. Evidence of effects ofenvironmental chemicals on the endocrine system in children.Pediatrics. 2003, 112 (1 Pt 2), 247-252.
  • [28] ten Tusscher, G. W. and Koppe, J. G. Perinatal dioxin exposureand later effects--a review. Chemosphere. 2004, 54 (9),1329-1336.[Crossref]
  • [29] James, W. H. Re: “Total serum testosterone and gonadotropinsin workers exposed to dioxin”. Am. J. Epidemiol. 1995, 141 (5),476-477.
  • [30] Jongbloet, P. H.; Roeleveld, N.; and Groenewoud, H. M. Wherethe boys aren’t: dioxin and the sex ratio. Environ. HealthPerspect. 2002, 110 (1), 1-3.
  • [31] Yu, M. L.; Guo, Y. L.; Hsu, C. C.; and Rogan, W. J. Menstruationand reproduction in women with polychlorinated biphenyl(PCB) poisoning: long-term follow-up interviews of the womenfrom the Taiwan Yucheng cohort. Int. J. Epidemiol. 2000, 29 (4),672-677.[Crossref]
  • [32] Yang, C. Y.; Huang, T. S.; Lin, K. C.; Kuo, P.; Tsai, P. C.; and Guo,Y. L. Menstrual effects among women exposed to polychlorinatedbiphenyls and dibenzofurans. Environ. Res. 2011, 111(2), 288-294.[Crossref]
  • [33] Eskenazi, B.; Warner, M.; Mocarelli, P.; Samuels, S.; Needham,L. L.; Patterson, D. G., Jr.; Lippman, S.; Vercellini, P.; Gerthoux,P. M.; Brambilla, P.; and Olive, D. Serum dioxin concentrationsand menstrual cycle characteristics. Am. J. Epidemiol. 2002,156 (4), 383-392.[Crossref]
  • [34] Mendola, P.; Buck, G. M.; Sever, L. E.; Zielezny, M.; and Vena,J. E. Consumption of PCB-contaminated freshwater fish andshortened menstrual cycle length. Am. J. Epidemiol. 1997, 146(11), 955-960.[Crossref]
  • [35] Kusuda, M. Yusho and female: studies on sexual functions infemale patients with rice oil poisoning. Sanka to Fuijnka. 1971,38 1063-1071.
  • [36] Cooper, G. S.; Klebanoff, M. A.; Promislow, J.; Brock, J. W.; andLongnecker, M. P. Polychlorinated biphenyls and menstrualcycle characteristics. Epidemiology. 2005, 16 (2), 191-200.[Crossref]
  • [37] Windham, G. C.; Lee, D.; Mitchell, P.; Anderson, M.; Petreas,M.; and Lasley, B. Exposure to organochlorine compoundsand effects on ovarian function. Epidemiology. 2005, 16 (2),182-190.[Crossref]
  • [38] Yang, C. Y.; Yu, M. L.; Guo, H. R.; Lai, T. J.; Hsu, C. C.; Lambert,G.; and Guo, Y. L. The endocrine and reproductive function ofthe female Yucheng adolescents prenatally exposed to PCBs/PCDFs. Chemosphere. 2005, 61 (3), 355-360.[Crossref]
  • [39] Chao, H. R.; Wang, S. L.; Lin, L. Y.; Lee, W. J.; and Papke, O.Placental transfer of polychlorinated dibenzo-p-dioxins,dibenzofurans, and biphenyls in Taiwanese mothers in relationto menstrual cycle characteristics. Food Chem. Toxicol. 2007,45 (2), 259-265.[Crossref]
  • [40] Koutras, D. A. Disturbances of menstruation in thyroid disease.Ann. N. Y. Acad. Sci. 1997, 816 280-284.
  • [41] Wheeler, J. M. Epidemiology of endometriosis-associatedinfertility. J. Reprod. Med. 1989, 34 (1), 41-46.
  • [42] Wheeler, J. M. Epidemiology and prevalence of endometriosis.Infertil. Reprod. Med. Clin. NA. 1992, 3 545-549.
  • [43] Wardle, P. G. and Hull, M. G. Is endometriosis a disease?Baillieres Clin. Obstet. Gynaecol. 1993, 7 (4), 673-685.
  • [44] Rier, S. and Foster, W. G. Environmental dioxins and endometriosis.Semin. Reprod. Med. 2003, 21 (2), 145-154.
  • [45] Beliard, A.; Noel, A.; and Foidart, J. M. Reduction of apoptosisand proliferation in endometriosis. Fertil. Steril. 2004, 82 (1),80-85.[Crossref]
  • [46] Eskenazi, B.; Mocarelli, P.; Warner, M.; Samuels, S.; Vercellini,P.; Olive, D.; Needham, L. L.; Patterson, D. G., Jr.; Brambilla, P.;Gavoni, N.; Casalini, S.; Panazza, S.; Turner, W.; and Gerthoux,P. M. Serum dioxin concentrations and endometriosis: a cohortstudy in Seveso, Italy. Environ. Health Perspect. 2002, 110 (7),629-634.[Crossref]
  • [47] Gerhard, I. and Runnebaum, B. [The limits of hormonesubstitution in pollutant exposure and fertility disorders].Zentralbl. Gynakol. 1992, 114 (12), 593-602.
  • [48] Pauwels, A.; Schepens, P. J.; D’Hooghe, T.; Delbeke, L.; Dhont,M.; Brouwer, A.; and Weyler, J. The risk of endometriosisand exposure to dioxins and polychlorinated biphenyls: acase-control study of infertile women. Hum. Reprod. 2001, 16(10), 2050-2055.[Crossref]
  • [49] Fierens, S.; Mairesse, H.; Heilier, J. F.; De Burbure, C.; Focant,J. F.; Eppe, G.; De Pauw, E.; and Bernard, A. Dioxin/polychlorinatedbiphenyl body burden, diabetes and endometriosis:findings in a population-based study in Belgium. Biomarkers.2003, 8 (6), 529-534.[Crossref]
  • [50] Heilier, J. F.; Nackers, F.; Verougstraete, V.; Tonglet, R.; Lison,D.; and Donnez, J. Increased dioxin-like compounds in theserum of women with peritoneal endometriosis and deependometriotic (adenomyotic) nodules. Fertil. Steril. 2005, 84(2), 305-312.[Crossref]
  • [51] De Felip, E.; Porpora, M. G.; di Domenico, A.; Ingelido, A. M.;Cardelli, M.; Cosmi, E. V.; and Donnez, J. Dioxin-like compoundsand endometriosis: a study on Italian and Belgian women ofreproductive age. Toxicol. Lett. 2004, 150 (2), 203-209.[Crossref]
  • [52] Trabert, B.; De Roos, A. J.; Schwartz, S. M.; Peters, U.; Scholes,D.; Barr, D. B.; and Holt, V. L. Non-dioxin-like polychlorinatedbiphenyls and risk of endometriosis. Environ. Health Perspect.2010, 118 (9), 1280-1285.[Crossref]
  • [53] Mayani, A.; Barel, S.; Soback, S.; and Almagor, M. Dioxinconcentrations in women with endometriosis. Hum. Reprod.1997, 12 (2), 373-375.[Crossref]
  • [54] Boyd, J. A.; Clark, G. C.; Walmer, D. K.; Patterson, D. G.;Needham, L. L.; and Lucier, G. W. Endometriosis and theenvironment: biomarkers of toxin exposure. 1995, 2000(Endometriosis),
  • [55] Birnbaum, L. S. and Cummings, A. M. Dioxins and endometriosis:a plausible hypothesis. Environ. Health Perspect. 2002,110 (1), 15-21.
  • [56] Lebel, G.; Dodin, S.; Ayotte, P.; Marcoux, S.; Ferron, L. A.; andDewailly, E. Organochlorine exposure and the risk of endometriosis.Fertil. Steril. 1998, 69 (2), 221-228.[Crossref]
  • [57] Louis, G. M.; Weiner, J. M.; Whitcomb, B. W.; Sperrazza, R.;Schisterman, E. F.; Lobdell, D. T.; Crickard, K.; Greizerstein, H.;and Kostyniak, P. J. Environmental PCB exposure and risk ofendometriosis. Hum. Reprod. 2005, 20 (1), 279-285.
  • [58] Porpora, M. G.; Ingelido, A. M.; di, D. A.; Ferro, A.; Crobu, M.;Pallante, D.; Cardelli, M.; Cosmi, E. V.; and De, F. E. Increasedlevels of polychlorobiphenyls in Italian women with endometriosis.Chemosphere. 2006, 63 (8), 1361-1367.[Crossref]
  • [59] Simsa, P.; Mihalyi, A.; Schoeters, G.; Koppen, G.; Kyama, C.M.; Den Hond, E. M.; Fulop, V.; and D’Hooghe, T. M. Increasedexposure to dioxin-like compounds is associated with endometriosisin a case-control study in women. Reprod. Biomed.Online. 2010, 20 (5), 681-688.[Crossref]
  • [60] Tsukino, H.; Hanaoka, T.; Sasaki, H.; Motoyama, H.; Hiroshima,M.; Tanaka, T.; Kabuto, M.; Niskar, A. S.; Rubin, C.; Patterson,D. G., Jr.; Turner, W.; Needham, L.; and Tsugane, S. Associationsbetween serum levels of selected organochlorine compoundsand endometriosis in infertile Japanese women. Environ. Res.2005, 99 (1), 118-125.[Crossref]
  • [61] Hoffman, C. S.; Small, C. M.; Blanck, H. M.; Tolbert, P.; Rubin,C.; and Marcus, M. Endometriosis among women exposedto polybrominated biphenyls. Ann. Epidemiol. 2007, 17 (7),503-510.[Crossref]
  • [62] Niskar, A. S.; Needham, L. L.; Rubin, C.; Turner, W. E.; Martin,C. A.; Patterson, D. G., Jr.; Hasty, L.; Wong, L. Y.; and Marcus, M.Serum dioxins, polychlorinated biphenyls, and endometriosis:a case-control study in Atlanta. Chemosphere. 2009, 74 (7),944-949.[Crossref]
  • [63] Wiberg, K.; Lindström, G.; Glas, B.; and Rappe, C. PCDDs andPCDFs in consumers’ paper products. Chemosphere. 1989, 19735-740.[Crossref]
  • [64] Scialli, A. R. Tampons, dioxins, and endometriosis. Reprod.Toxicol. 2001, 15 (3), 231-238.[Crossref]
  • [65] Dizerega, G. S.; Barber, D. L.; and Hodgen, G. D. Endometriosis:role of ovarian steroids in initiation, maintenance, andsuppression. Fertil. Steril. 1980, 33 (6), 649-653.
  • [66] Ohtake, F.; Takeyama, K.; Matsumoto, T.; Kitagawa, H.;Yamamoto, Y.; Nohara, K.; Tohyama, C.; Krust, A.; Mimura, J.;Chambon, P.; Yanagisawa, J.; Fujii-Kuriyama, Y.; and Kato, S.Modulation of oestrogen receptor signalling by associationwith the activated dioxin receptor. Nature. 2003, 423 (6939),545-550.
  • [67] Guo, Y. L.; Hsu, P. C.; Hsu, C. C.; and Lambert, G. H. Semenquality after prenatal exposure to polychlorinated biphenylsand dibenzofurans. Lancet. 2000, 356 (9237), 1240-1241.
  • [68] Rozati, R.; Reddy, P. P.; Reddanna, P.; and Mujtaba, R. Role ofenvironmental estrogens in the deterioration of male factorfertility. Fertil. Steril. 2002, 78 (6), 1187-1194.[Crossref]
  • [69] Dallinga, J. W.; Moonen, E. J.; Dumoulin, J. C.; Evers, J. L.;Geraedts, J. P.; and Kleinjans, J. C. Decreased human semenquality and organochlorine compounds in blood. Hum. Reprod.2002, 17 (8), 1973-1979.[Crossref]
  • [70] Hauser, R.; Altshul, L.; Chen, Z.; Ryan, L.; Overstreet, J.;Schiff, I.; and Christiani, D. C. Environmental organochlorinesand semen quality: results of a pilot study. Environ. HealthPerspect. 2002, 110 (3), 229-233.[Crossref]
  • [71] Henriksen, G. L. and Michalek, J. E. Serum dioxin, testosterone,and gonadotropins in veterans of Operation Ranch Hand.Epidemiology. 1996, 7 (4), 454-455.
  • [72] Donovan, J. W.; MacLennan, R.; and Adena, M. Vietnam serviceand the risk of congenital anomalies. A case-control study.Med. J. Aust. 1984, 140 (7), 394-397.
  • [73] Stellman, S. D.; Stellman, J. M.; and Sommer, J. F., Jr. Healthand reproductive outcomes among American Legionnaires inrelation to combat and herbicide exposure in Vietnam. Environ.Res. 1988, 47 (2), 150-174.[Crossref]
  • [74] Toft, G.; Long, M.; Kruger, T.; Hjelmborg, P. S.; Bonde, J. P.;Rignell-Hydbom, A.; Tyrkiel, E.; Hagmar, L.; Giwercman, A.;Spano, M.; Bizzaro, D.; Pedersen, H. S.; Lesovoy, V.; Ludwicki,J. K.; and Bonefeld-Jorgensen, E. C. Semen quality in relation toxenohormone and dioxin-like serum activity among Inuits andthree European populations. Environ. Health Perspect. 2007,115 Suppl 1 15-20.
  • [75] Mocarelli, P.; Gerthoux, P. M.; Patterson, D. G., Jr.; Milani, S.;Limonta, G.; Bertona, M.; Signorini, S.; Tramacere, P.; Colombo,L.; Crespi, C.; Brambilla, P.; Sarto, C.; Carreri, V.; Sampson, E. J.;Turner, W. E.; and Needham, L. L. Dioxin exposure, from infancythrough puberty, produces endocrine disruption and affectshuman semen quality. Environ. Health Perspect. 2008, 116 (1),70-77.
  • [76] Mocarelli, P.; Gerthoux, P. M.; Needham, L. L.; Patterson, D. G.,Jr.; Limonta, G.; Falbo, R.; Signorini, S.; Bertona, M.; Crespi, C.;Sarto, C.; Scott, P. K.; Turner, W. E.; and Brambilla, P. Perinatalexposure to low doses of dioxin can permanently impair humansemen quality. Environ. Health Perspect. 2011, 119 (5), 713-718.[Crossref]
  • [77] Jorgensen, N.; Andersen, A. G.; Eustache, F.; Irvine, D. S.;Suominen, J.; Petersen, J. H.; Andersen, A. N.; Auger, J.;Cawood, E. H.; Horte, A.; Jensen, T. K.; Jouannet, P.; Keiding,N.; Vierula, M.; Toppari, J.; and Skakkebaek, N. E. Regionaldifferences in semen quality in Europe. Human Reproduction.2001, 16 (5), 1012-1019.[Crossref]
  • [78] Guo, Y. L.; Lambert, G. H.; Hsu, C. C.; and Hsu, M. M. Yucheng:health effects of prenatal exposure to polychlorinatedbiphenyls and dibenzofurans. Int. Arch. Occup. Environ. Health.2004, 77 (3), 153-158.[Crossref]
  • [79] Govarts, E.; Nieuwenhuijsen, M.; Schoeters, G.; Ballester, F.;Bloemen, K.; de, B. M.; Chevrier, C.; Eggesbo, M.; Guxens, M.;Kramer, U.; Legler, J.; Martinez, D.; Palkovicova, L.; Patelarou,E.; Ranft, U.; Rautio, A.; Petersen, M. S.; Slama, R.; Stigum,H.; Toft, G.; Trnovec, T.; Vandentorren, S.; Weihe, P.; Kuperus,N. W.; Wilhelm, M.; Wittsiepe, J.; and Bonde, J. P. Birth weightand prenatal exposure to polychlorinated biphenyls (PCBs)and dichlorodiphenyldichloroethylene (DDE): a meta-analysiswithin 12 European Birth Cohorts. Environ. Health Perspect.2012, 120 (2), 162-170.
  • [80] Kezios KL; Liu X; Cirillio PM; Kalantzi OI; Wang Y, P. M.; PArkJS; Bradwin G; Cohn BA; and Factor-Litvak P Prenatal polychlorinatedbiphenyl exposure is associated with decreasedgestational length but not birthweight:archived samples fromthe Child Health and development Studies pregnaancy cohort.Environmental Health. 2012, 11 49-[Crossref]
  • [81] Ferguson KK; O’Neill MS; and Meeker JD Environmentalcontaminant exposures and preterm birth:a comprehensiveview. J Toxicol Environ health B Crit Rev. 2013, 16 (2), 69-113.
  • [82] Vafeiadi M; Agramunt S; Pedersen M; Besselink H; ardie LJ;unyer J; arreras R; Brunborg G; utzkow KB; ygaard UC; ovikM; Kyrtopoulos SA; egerback D; erlo DF; elinjans JC; VrijheidM; and ogevinas M In Utero Exposure to Compounds withDioxin-like Activity and Birth Outcomes. Epidemiology. 2014,25 (2), 215-224. [Crossref]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_bimo-2014-0001
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