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2004 | 2 | 4 | 686-695
Article title

Synthesis of a series of vicinal diamines with potential biological activity

Content
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EN
Abstracts
EN
A broad range of vicinal diamines based on styrene oxide are synthesisedvia mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds are in progress.
Publisher

Journal
Year
Volume
2
Issue
4
Pages
686-695
Physical description
Dates
published
1 - 12 - 2004
online
1 - 12 - 2004
Contributors
author
  • Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl.9, 1113, Sofia, Bulgaria, vkurteva@orgchm.bas.bg
author
  • Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl.9, 1113, Sofia, Bulgaria
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_BF02482731
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