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2004 | 2 | 4 | 563-572

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HPLC monitored synthesis of R2NCH2 substituted benzene derivatives used as (C,N)-ligands for organometallic compounds


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2-(Diethylaminomethyl)phenyl bromide and 1,3-bis(dimethylaminomethyl)-benzene, useful ligands for the synthesis of hypervalent organometallic compounds, were prepared and characterized by NMR (1H, 13C, 2D experiments) spectroscopy. Their synthesis was monitored by the HPLC method. The compounds were eluted on a Nucleosil 120 Si column (5 μm, 25×0.4 cm) with n-hexane at room temperature using a 1.0 ml/min flow-rate. The maximum values of absorbance for the studied compounds, excepting the diethylamine, were located in a narrow range around 212 nm, the wavelength used for their UV detection. The diethylamine was detected at 190 nm. The calibration curves are straight lines with correlation factors r>0.995. The HPLC data are in good agreement with those provided by NMR spectroscopy.










Physical description


1 - 12 - 2004
1 - 12 - 2004


  • “Raluca Ripan” Institute for Research in Chemistry, 30 Fântânele Street, P.O. Box 702, RO-400294, Cluj-Napoca, Romania
  • “Raluca Ripan” Institute for Research in Chemistry, 30 Fântânele Street, P.O. Box 702, RO-400294, Cluj-Napoca, Romania
  • Faculty of Chemistry and Chemical Engineering, “Babeş-Bolyai” University, 11 Arany Janos Street, RO-400028, Cluj-Napoca, Romania
  • Faculty of Chemistry and Chemical Engineering, “Babeş-Bolyai” University, 11 Arany Janos Street, RO-400028, Cluj-Napoca, Romania


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