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2003 | 1 | 3 | 260-276

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Synthesis of 4-aryloxy-7-nitrobenzofurazan derivatives from 4-chloro-7-nitrobenzofurazan and various phenoxide anions (including pharmaceuticals) in the presence of crown ethers


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4-Chloro-7-nitrobenzofurazan reacts by nucleophilic substitution with phenoxide anions derived from estriol (2c), ethynylestradiol (2d), phenol (3e), guaiacol (3f), 2,6-dimethoxyphenol (3g), eugenol (3h), isoeugenol (3i), the cytostatic Etoposide (4), and Reichardt’s betaine (5) in the presence of crown ethers affording the corresponding 4-aryloxy-7-nitrobenzofurazan derivatives 6c, 6d, 7e-7i, 8, and 9. The structure of these compounds was confirmed by NMR spectra. Hydrophobicity/hydrophilicity parameters were investigated by reverse phase thin-layer chromatography.










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1 - 9 - 2003
1 - 9 - 2003


  • Laboratory of Supramolecular Chemistry and Interphase Processes, Institute “I.G. Murgulescu” of Physical Chemistry, Roumanian Academy, Splaiul Independentei 202, 77208, Bucharest, Roumania
  • Institute “C.D. Nenitzescu” of Organic Chemistry, Roumanian Academy, Splaiul Independentei 202 B, Bucharest, Roumania
  • SINDAN SRL Pharmaceutical Company, Ion Mihalache Blvd. 11, 781681, Bucharest, Roumania
  • Laboratory of Supramolecular Chemistry and Interphase Processes, Institute “I.G. Murgulescu” of Physical Chemistry, Roumanian Academy, Splaiul Independentei 202, 77208, Bucharest, Roumania
  • Texas A&M University at Galveston, 5007 Ave. U, 77553-1675, Galveston, TX, USA


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