Phosphorus (V) porphyrin diaxially substituted with Leu-enkephalin

• Authors: Mariusz Gajewski , Leszek Czuchajowski
• Languages of publication: EN

Abstracts

EN

Synthesis of the first phosphorus (V) porphyrin-peptide conjugate was successfully accomplished. A biologically active peptide, leucine enkephalin, was constructed on the phosphorus atom of the 5,10,15,20-meso-tetraphenylporphinato dichlorophosphorus (V) chloride. The method involved solution phase peptide synthesis. The first C-terminal amino acid in the sequence of the peptide was axially attached to the porphyrin through a linker, 3-aminopropanol, and the remainder of leucine enkephalin was synthesized by subsequent additions of amino acids. Leucine enkephalin-P(V) porphyrin conjugate represents a new group of compounds, and its synthesis broadens potential applications of P(V) porphyrine, e.g. in photodynamic therapy.

Keywords

EN

phosphorus (V) porphyrins; photosensitizers; peptide-P(V) porphyrins; enkephalin; peptide synthesis

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2004
• Volume: 2
• Issue: 3
• Pages: 446-455

Dates

published

1 - 9 - 2004

online

1 - 9 - 2004

Contributors

author

Mariusz Gajewski

• Department of Chemistry, University of Idaho, 83844, Moscow, ID, USA

author

Leszek Czuchajowski

• Department of Chemistry, University of Idaho, 83844, Moscow, ID, USA

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Identifiers

DOI

10.2478/BF02476200