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Journal
2004 | 2 | 3 | 446-455
Article title

Phosphorus (V) porphyrin diaxially substituted with Leu-enkephalin

Content
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EN
Abstracts
EN
Synthesis of the first phosphorus (V) porphyrin-peptide conjugate was successfully accomplished. A biologically active peptide, leucine enkephalin, was constructed on the phosphorus atom of the 5,10,15,20-meso-tetraphenylporphinato dichlorophosphorus (V) chloride. The method involved solution phase peptide synthesis. The first C-terminal amino acid in the sequence of the peptide was axially attached to the porphyrin through a linker, 3-aminopropanol, and the remainder of leucine enkephalin was synthesized by subsequent additions of amino acids. Leucine enkephalin-P(V) porphyrin conjugate represents a new group of compounds, and its synthesis broadens potential applications of P(V) porphyrine, e.g. in photodynamic therapy.
Publisher
Journal
Year
Volume
2
Issue
3
Pages
446-455
Physical description
Dates
published
1 - 9 - 2004
online
1 - 9 - 2004
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_BF02476200
Identifiers
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