Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives

• Authors: Sham Sondhi , Gurudas Bhattacharjee , Rafid Jameel , Rakesh Shukla , Ram Raghubir , Olivier Lozach , Laurent Meijer
• Languages of publication: EN

Abstracts

EN

9-Chloro-2,4-(un)substituted acridines (1) on condensation with sulpha- diazine, sulphathiazole, and sulphaacetamide gave condensation products 3a-h. 3-Aryl-4-phenyl-2-imino-4-thiazolines (4) on condensation with 9-chloro-2,4-(un)substituted acridines (1) gave condensation products 5a–5o. Both 3a–3h and 5a–5o were purified by crystallization or by chromatography. Structures assigned to 3a–3h and 5a–5o are supported by correct spectral data. Antiinflammatory and analgesic activity screening of 3a, 3e, 3f and 5a–5c, 5e, 5g, 5i, 5m, 5n were carried out using carrageenin induced paw oedema and phenyl quinone writhing assay. Some of the compounds exhibited interesting antiinflammatory or analgesic activities.

Keywords

EN

acridine derivatives; antiinflammatory; analgesic; 1H NMR; HRMS

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2004
• Volume: 2
• Issue: 1
• Pages: 1-15

Dates

published

1 - 3 - 2004

online

1 - 3 - 2004

Contributors

author

Sham Sondhi

• Department of Chemistry, Indian Institute of Technology, 247667, Roorkee, U.A., India

author

Gurudas Bhattacharjee

• Department of Chemistry, Indian Institute of Technology, 247667, Roorkee, U.A., India

author

Rafid Jameel

• Department of Chemistry, Indian Institute of Technology, 247667, Roorkee, U.A., India

author

Rakesh Shukla

• Division of Pharmacology, Central Drug Research Insitute, Lucknow-226001, U.P., India

author

Ram Raghubir

• Division of Pharmacology, Central Drug Research Insitute, Lucknow-226001, U.P., India

author

Olivier Lozach

• Centre National De La Recherche Scientifique, Station Biologique, 29680-Roscoff, Bretagne, France

author

Laurent Meijer

• Centre National De La Recherche Scientifique, Station Biologique, 29680-Roscoff, Bretagne, France

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Identifiers

DOI

10.2478/BF02476181