Synthesis, structural and conformational study of selected N-substituted phthalimides

• Authors: Isabel Iriepa , F. Javier Villasante , Enrique Gálvez , Antonio Herrera , Angel Sánchez , Felix Cano
• Languages of publication: EN

Abstracts

EN

This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.

Keywords

EN

Phthalimides; NMR spectroscopy; structural analysis

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2005
• Volume: 3
• Issue: 4
• Pages: 683-704

Dates

published

1 - 12 - 2005

online

1 - 12 - 2005

Contributors

author

Isabel Iriepa

• Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain

author

F. Javier Villasante

• Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain

author

Enrique Gálvez

• Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain

author

Antonio Herrera

• Universidad Complutense de Madrid, 28006, Madrid, Spain

author

Angel Sánchez

• Universidad Complutense de Madrid, 28006, Madrid, Spain

author

Felix Cano

• Instituto de Química Fisica Rocasolano, (CSIC), 28006, Madrid, Spain

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Identifiers

DOI

10.2478/BF02475197