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2005 | 3 | 4 | 683-704

Article title

Synthesis, structural and conformational study of selected N-substituted phthalimides


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This paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.










Physical description


1 - 12 - 2005
1 - 12 - 2005


  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
  • Dpto. Química Orgánica, Universidad de Alcalá, Ctra. Madrid-Barcelona Km. 33.600, 28871, Alcalá de Henares, Madrid, Spain
  • Universidad Complutense de Madrid, 28006, Madrid, Spain
  • Universidad Complutense de Madrid, 28006, Madrid, Spain
  • Instituto de Química Fisica Rocasolano, (CSIC), 28006, Madrid, Spain


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