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2005 | 3 | 4 | 622-646

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Reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides and their biological activity


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The reactions of substituted furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5-arylfuran-2-carboxaldehydes 2, 4,5-disubstituted furan-2-carboxaldehydes 3 and thiophene-2-carboxaldehyde 4 has been studied. The advantage of microwave irradiation on some of these reactions was reflected in the reduced reaction time and increased yields. Reactions of 1 with 4-substituted 1,3-oxazol-5(4H)-ones 11 led to diacylhydrazines 13 or to imidazole derivatives 14 depending on the temperature. 1,2,4-Triazole-3-thione 17 was synthesized by two-step reaction of 1 with phenylisothiocyanate and subsequent base-catalyzed cyclization of thiosemicarbazide 16. The effects of hydrazones 5–10 on inhibition of photosynthetic electron transport in spinach chloroplasts and chlorophyll content in the antialgal suspensions of Chlorella vulgaris were investigated.










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1 - 12 - 2005
1 - 12 - 2005


  • Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie Jozefa Herdu 2, Sk-917 01, Trnava, Slovak Republic
  • Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie Jozefa Herdu 2, Sk-917 01, Trnava, Slovak Republic
  • Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, SK 842 15, Bratislava, Slovak Republic
  • Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, SK 842 15, Bratislava, Slovak Republic
  • Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, SK 842 15, Bratislava, Slovak Republic
  • Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, Námestie Jozefa Herdu 2, Sk-917 01, Trnava, Slovak Republic


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