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2014 | 2 | 1 |
Article title

The isolation and characterisation of the synthetic
cannabinoid AM-2201 from commercial products
using purification by HPLC-DAD

Content
Title variants
Languages of publication
EN
Abstracts
EN
A total of six products containing legal highs
were purchased via the internet from the UK- based
retailers and screened for the presence of synthetic
cannabinoids using a fast GC-MS method and identified,
in the absence of reference materials, by comparing the
mass spectra with the Scientific Working Group for the
Analysis of Seized Drugs (SWGDRUG) mass spectral
library. Four synthetic cannabinoids were detected: RCS-4,
CP-47, 497, UR-144 and AM-2201. The active ingredient
(1-(5-fluoropentyl)-3-(1-naphthoyl) indole), with the street
name AM-2201, detected in the product named Doob was
isolated and purified from the methanolic extract of the
product using preparative HPLC with analytical column
(column overloading method). The structure of the
substance was confirmed using NMR. This approach used
common analytical equipment found in forensic and other
analytical laboratories (except for the NMR), therefore can
be useful for the identification of unknown psychoactive
substances in drugs of abuse.
Publisher

Year
Volume
2
Issue
1
Physical description
Dates
online
15 - 6 - 2015
received
19 - 11 - 2014
accepted
6 - 5 - 2015
Contributors
  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS
author
  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS
author
  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_sampre-2015-0004
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