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Number of results
2014 | 2 | 1 |

Article title

The isolation and characterisation of the synthetic
cannabinoid AM-2201 from commercial products
using purification by HPLC-DAD


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A total of six products containing legal highs
were purchased via the internet from the UK- based
retailers and screened for the presence of synthetic
cannabinoids using a fast GC-MS method and identified,
in the absence of reference materials, by comparing the
mass spectra with the Scientific Working Group for the
Analysis of Seized Drugs (SWGDRUG) mass spectral
library. Four synthetic cannabinoids were detected: RCS-4,
CP-47, 497, UR-144 and AM-2201. The active ingredient
(1-(5-fluoropentyl)-3-(1-naphthoyl) indole), with the street
name AM-2201, detected in the product named Doob was
isolated and purified from the methanolic extract of the
product using preparative HPLC with analytical column
(column overloading method). The structure of the
substance was confirmed using NMR. This approach used
common analytical equipment found in forensic and other
analytical laboratories (except for the NMR), therefore can
be useful for the identification of unknown psychoactive
substances in drugs of abuse.







Physical description


15 - 6 - 2015
19 - 11 - 2014
6 - 5 - 2015


  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS
  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS
  • School of Chemistry,
    University of Lincoln, Lincoln, United Kingdom LN6 7TS


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