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Number of results
2015 | 2 | 1 |

Article title

Aptamer guided delivery of nucleic acid-based
nanoparticles

Content

Title variants

Languages of publication

EN

Abstracts

EN
Targeted delivery of bioactive compounds is a
key part of successful therapies. In this context, nucleic
acid and protein-based aptamers have been shown to
bind therapeutically relevant targets including receptors.
In the last decade, nucleic acid-based therapeutics
coupled to aptamers have emerged as a viable strategy for
cell specific delivery. Additionally, recent developments
in nucleic acid nanotechnology offer an abundance of
possibilities to rationally design aptamer targeted RNA
or DNA nanoparticles involving combinatorial use of
various intrinsic functionalities. Although a host of issues
including stability, safety and intracellular trafficking
remain to be addressed, aptamers as simple functional
chimeras or as parts of multifunctional self-assembled
RNA/DNA nanostructures hold great potential for clinical
applications.

Publisher

Year

Volume

2

Issue

1

Physical description

Dates

received
15 - 7 - 2015
online
21 - 1 - 2016
accepted
3 - 10 - 2015

Contributors

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_rnan-2015-0005
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