Autophagy - Adaptive Molecular Mechanisms in Condition of Starvation

• Authors: Agnieszka Pedrycz , Małgorzata Tomasiak , Beata Cichacz
• Languages of publication: EN

Abstracts

EN

Autophagy is an extremely old process during which long-lived proteins and cellular organelles are removed by means of lysosomes. Autophagy may be caused by cellular stress mechanisms. Research has proven that autophagy plays a key role in obtaining nutrients and adapting to the conditions of starvation. Owing to this, it takes part in maintaining homeostasis in cytoplasm and cell nucleus. This objective may be achieved through a number of ways. Depending on the manner in which a substrate connects with the lysosome, we can talk about macroautophagy and microautophagy. Additionally, some authors also distinguish a chaperone-mediated autophagy. The article presented below describes molecular mechanisms of each type of autophagy and focuses particularly on macroautophagy, which is the best understood of all the autophagy types.

Keywords

EN

autophagy; cellular starvation; lysosome; cell death

• Publisher: De Gruyter Open
• Journal: Polish Hyperbaric Research
• Year: 2015
• Volume: 52
• Issue: 3
• Pages: 71-73

Dates

published

1 - 9 - 2015

accepted

20 - 7 - 2015

online

30 - 12 - 2015

received

5 - 6 - 2015

Contributors

author

Agnieszka Pedrycz

• Departament of Histology and Embryology Medical University in Lublin ul. Radziwiłłowska 11 20-080, Lublin, Poland

author

Małgorzata Tomasiak

• Departament of Histology and Embryology Medical University in Lublin, Poland

author

Beata Cichacz

• Departament of Histology and Embryology Medical University in Lublin, Poland

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Identifiers

DOI

10.1515/phr-2015-0018