Initial Tests on Selected Serological Reactions in Rabbits Burnt with Napalm and Subjected to Hyperbaric Oxygenation

• Authors: Kazimierz Ulewicz , Przemysław Michniewski , Brunon Kierznikowicz , Bogdan Łokucijewski , Jan Stencel
• Languages of publication: EN

Abstracts

EN

Hyperbaric oxygenation therapy has found its application in the treatment of various types of burns. The presented work describes the use of this method in treating napalm burns in experimental animals. The researchers took particular interest in the immunological reactions occurring in animals, as well as the effect of the said therapy on the healing process. Two groups of rabbits, previously anaesthetised with Evipan and immunised with S. typhi phage F7 microorganisms, were burnt with the use of napalm. The tested group was subjected to a series of treatment sessions with 100% oxygen at the pressure of 2 atm, whereas the control group did not undergo such treatment. Six repeated tests on complement activity with 50% haemolysis method and heamagglutination reaction quantification with antigens O and H S.typhi phage F7 were carried out on all of the researched animals. Moreover, for the purpose of control of the healing process, a number of histopathological exams on the burn wounds were conducted in both groups of rabbits. The research showed an increase in complement activity in all tested animals; however, in the tested group it occurred later. Histopathological tests confirmed a more advanced healing process in the group subjected to hyperbaric oxygenation.

Keywords

EN

Hyperbaric oxygenation therapy; complement activity reaction; haemagglutination reaction; burn wound histopathology

• Publisher: De Gruyter Open
• Journal: Polish Hyperbaric Research
• Year: 2015
• Volume: 50
• Issue: 1
• Pages: 41-45

Dates

published

1 - 3 - 2015

online

20 - 10 - 2015

Contributors

author

Kazimierz Ulewicz

• Maritime Medicine Departament Military Medical University, Gdynia, Poland

author

Przemysław Michniewski

• Maritime Medicine Departament Military Medical University, Gdynia, Poland

author

Brunon Kierznikowicz

• Maritime Medicine Departament Military Medical University, Gdynia, Poland

author

Bogdan Łokucijewski

• Maritime Medicine Departament Military Medical University, Gdynia, Poland

author

Jan Stencel

• Pathology Departament 8 Naval Hospital, Gdańsk, Poland

References

• 1. Doboszyński T., Ulewicz K., Łokucijewski B., Michniewski P.,: Ann.Immunol. 1970.4;245.
• 2. Dolatkowski A., Ulewicz K., (ed.): The outline of physiopathology of diving. PZWL. Warsaw 1973.
• 3. Harter F.: Arzl.Mitt. 1962.47/59;2503.
• 4. Ingestad R., Winblad A.: Acta path.microb.scand. 1963.57;455.
• 5. Moretti G., Fontanesi S., Chittoni L.: Annali di Med. Navale. 1973.48.1;11.
• 6. Niedworok J.: Experimental studies on the immunological phenomena in napalm-induced burn disease. Łódź 1973.
• 7. Proceedings of the Fourth International Congress on of Hyperbaric Medicine. Ed.Brown j.Jr., Cox B.Washington 1966.
• 8. Proceedings of the Fourth International Conference on Hyperbaric Medicine. Ed.Wada J., Iwa T. Tokyo. 1970.
• 9. Ulewicz K.: Ann.Immunol.Hung. 1971.15;121.
• 10. Ulewicz K., Michniewski P.: Ann.Immunol.Hung. 1971.15;129.
• 11. Ulewicz K., Michniewski P., Łokucijewski B., Doboszyński T.: Przegl.Lek. 1971.9;581.
• 12. Zanini D., Bogetti B., Arkel F.: Lav.e Med. 1966.20;4;175.
• 13. Zenini D., Bogetti B., Viotti G.: Lav.e Med. 1967.21.5;177.

Identifiers

DOI

10.1515/phr-2015-0005