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Journal

2015 | 2 | 1 |

Article title

Serum metal evaluation in a small cohort of
Amyotrophic Lateral Sclerosis patients reveals
high levels of thiophylic species

Content

Title variants

Languages of publication

EN

Abstracts

EN
Amyotrophic Lateral Sclerosis (ALS) has often
been associated with improper/altered metal metabolism.
Analysis of thiophylic metals in serum from a small and
geographically restricted cohort of ALS patients indicates
contents of Pb and Ni much higher in patients than in
controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in
the patients’ group, which has instead lower As levels than
controls. Thiophylic metals may impair biogenesis of FeS
clusters or substitute for iron, even in folded proteins; Se
may non-functionally replace S. Thus, improper assembly/
function of FeS proteins could represent another possible
issue to be considered in ALS pathogenesis.

Publisher

Journal

Year

Volume

2

Issue

1

Physical description

Dates

accepted
16 - 10 - 2015
online
20 - 1 - 2016
received
28 - 7 - 2015

Contributors

  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • Department of Agricultural and Environmental
    Sciences (DiSAA), University of Milan, 20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
author
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • NEuroMuscular Omnicentre (NEMO), Fondazione
    Serena Onlus, Niguarda Ca’ Granda Hospital, 20169, Milan, Italy
  • DeFENS, University of
    Milan, Via Celoria 2, 20133, Milan, Italy
  • Proteomics and Protein Structure Study Group,
    Division of Pharmacological Sciences, Department of Pharmacological
    and Biomolecular Sciences (DiSFeB), University of Milan, 20133
    Milano, Italy
  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy

References

  • [1] Chiò A., Logroscino G., Traynor B.J., Collins J., Simeone J.C.,Goldstein L.A., White L.A., Global epidemiology of amyotrophiclateral sclerosis: a systematic review of the publishedliterature, Neuroepidemiology, 2013, 41, 118-30.[WoS]
  • [2] Mitchell J.D., Borasio G.D., Amyotrophic lateral sclerosis,Lancet, 2007, 369, 2031-2041.
  • [3] McLaughlin R.L., Vajda A., Hardiman O., Heritability ofAmyotrophic Lateral Sclerosis: Insights From DisparateNumbers., JAMA Neurol Published online June 01, 2015.doi:10.1001/jamaneurol.2014.4049.[Crossref]
  • [4] Rosen D.R., Siddique T., Patterson D., Figlewicz D.A., Sapp P.,Hentati, A., Donaldson D., Goto J., O’Regan J.P., Deng H.X.,et al., Mutations in Cu/Zn superoxide dismutase gene areassociated with familial amyotrophic lateral sclerosis, Nature,1993, 362, 59–62.
  • [5] Sreedharan J., Blair I.P., Tripathi V.B., Hu X., Vance C., RogeljB., Ackerley S., Durnall J.C., Williams K.L., Buratti E., et al.,TDP-43 mutations in familial and sporadic amyotrophic lateralsclerosis, Science, 2008, 319, 1668–1672.[WoS]
  • [6] Vance C., Rogelj B., Hortobgàyi T., De Vos K.J., Nishimura A.L.,Sreedharan J., Hu X., Smith B., Ruddy D., Wright P., et al.,Mutations in FUS, an RNA processing protein, cause familialamyotrophic lateral sclerosis type 6, Science, 2009, 323,1208–1211.[WoS]
  • [7] DeJesus-Hernandez M., Mackenzie I.R., Boeve B.F., Boxer A.L.,Baker M., Rutherford N.J., Nicholson A.M., Finch N.A., Flynn H.,Adamson J., et al., Expanded GGGGCC hexanucleotide repeat innoncoding region of C9ORF72 causes chromosome 9p-linkedFTD and ALS, Neuron, 2011, 72, 245–456.[WoS]
  • [8] Renton A.E., Majounie E., Waite A., Simón-Sánchez J., RollinsonS., Gibbs J.R., Schymick J.C., Laaksovirta H., van Swieten J.C.,Myllykangas L., et al., A hexanucleotide repeat expansion inC9ORF72 is the cause of chromosome 9p21-linked ALS-FTD,Neuron, 2011, 72, 257–268.[WoS]
  • [9] Brooks B.R., Miller R.G., Swash M., Munsat T.L., WorldFederation of Neurology Research Group on Motor NeuronDiseases. El Escorial revisited: revised criteria for the diagnosisof amyotrophic lateral sclerosis, Amyotroph Lateral Scler OtherMotor Neuron Disord, 2000, 1(5), 293-9.
  • [10] Crichton R.R., Ward R.J., Metal-based neurodegeneration. Frommolecular mechanisms to therapeutic strategies, John Wileyand Sons, pp 227, 2006.
  • [11] Hadzhieva M., Kirches E., Mawrin C., Review: iron metabolismand the role of iron in neurodegenerative disorders,Neuropathol Appl Neurobiol, 2014, 40(3), 240-57.[WoS][Crossref]
  • [12] Carrí M.T., Ferri A., Cozzolino M., Calabrese L., Rotilio G.,Neurodegeneration in amyotrophic lateral sclerosis: the role ofoxidative stress and altered homeostasis of metals, Brain ResBull, 2003, 61(4), 365-74.
  • [13] Goodall E.F., Haque M.S., Morrison K.E., Increased serumferritin levels in amyotrophic lateral sclerosis (ALS) patients, JNeurol, 2008, 255(11),1652-6.
  • [14] Nadjar Y., Gordon P., Corcia P., Bensimon G., Pieroni L.,Meininger V., Salachas F., Elevated serum ferritin is associatedwith reduced survival in amyotrophic lateral sclerosis, PLoSOne, 2012, 7(9), e45034.
  • [15] Roos P.M., Lierhagen S., Flaten T.P., Syversen T., VesterbergO., Nordberg M., Manganese in cerebrospinal fluid and bloodplasma of patients with amyotrophic lateral sclerosis, Exp BiolMed (Maywood), 2012, 237(7), 803-10.[WoS]
  • [16] Buscema M., Penco S., Grossi E., A Novel MathematicalApproach to Define the Genes/SNPs Conferring Risk or Protection in Sporadic Amyotrophic Lateral Sclerosis Basedon Auto Contractive Map Neural Networks and Graph Theory,Neurol Res Int., 2012, 478560.
  • [17] ISTISAN, Alimonti A., Bocca B., Mattei D., Pino A., 2010.Report 10/22: Biomonitoraggio della popolazioneitaliana per l’esposizione ai metalli: valori di riferimento1990–2009
  • [Biomonitoring of Italian population for metalsexposure: reference values 1990–2009]. ISSN: 1123-3117.Istutito Superiore della Sanità
  • [Italian Superior HealthInstitute], Available at: http://www.iss.it/ binary/publ/cont/10ventidueWEB.pdf. Accessed May 2015.
  • [18] Ingre C., Roos P.M., Piehl F., Kamel F., Fang F., Risk factors foramyotrophic lateral sclerosis, Clin Epidemiol, 2015, 7, 181-93.
  • [19] Penco S., Lunetta C., Mosca L., Maestri E., Avemaria F.,Tarlarini C., Patrosso M.C., Marocchi A., Corbo M., PhenotypicHeterogeneity in a SOD1 G93D Italian ALS Family: An Exampleof Human Model to Study a Complex Disease, J Mol Neurosci,2011, 44, 25–30.[WoS][Crossref]
  • [20] Chio` A., Calvo A., Moglia C., Mazzini L., Mora G., PARALSstudy group, Phenotypic heterogeneity of amyotrophic lateralsclerosis: a population based study, J Neurol NeurosurgPsychiatry, 2011 , 82, 740-746.[WoS]
  • [21] Marescotti P., Azzali E., Servida D., Carbone C., Grieco G., deCapitani L., Lucchetti G., Mineralogical and geochemical spatialanalyses of a waste-rock dump at the Libiola Fe-Cu sulphidemine (Eastern Liguria, Italy), Environmental Earth Sciences,2010, 61 (1), 187-199.[WoS]
  • [22] Oh S.S., Kim E.A., Lee S.W., Kim M.K., Kang S.K., A case ofamyotrophic lateral sclerosis in electronic parts manufacturingworker exposed to lead, Neurotoxicology, 2007, 28, 324–327.[WoS]
  • [23] Fang F., Kwee L.C., Allen K.D., Umbach D.M., Ye W., WatsonM., Keller J., Oddone E.Z., Sandler D.P., Schmidt S., et al.,Association between blood lead and the risk of amyotrophiclateral sclerosis, Am. J. Epidemiol, 2010, 171, 1126–1133.
  • [24] Vinceti M., Guidetti D., Bergomi M., Caselgrandi E., Vivoli R.,Olmi M., Rinaldi L., Rovesti S., Solime F., Lead, cadmium, andselenium in the blood of patients with sporadic amyotrophiclateral sclerosis, Ital. J. Neurol. Sci., 1997, 18, 87–92.[Crossref]
  • [25] Roos P.M., Vesterberg O., Syversen T., Peder Flaten T., NordbergM., Metal concentrations in cerebrospinal fluid and bloodplasma from patients with amyotrophic lateral sclerosis, Biol.Trace Elem. Res, 2013, 151, 159–170.[WoS]
  • [26] Iametti S., Uhlmann H., Sala N., Bernhardt R., Ragg E.M.,Bonomi F., Reversible, non-denaturing metal substitution inbovine adrenodoxin and spinach ferredoxin and the differentreactivity of
  • [2Fe-2S]-cluster-containing proteins, Eur. J.Biochem., 1996, 239, 818-826.
  • [27] Iametti S., Uhlmann H., Ragg E.M., Sala N., Grinberg A., BeckertV., Bernhardt R., Bonomi F., Cluster iron substitution is relatedto structural and functional features of adrenodoxin mutantsand to their redox state, Eur. J. Biochem., 1998, 251, 673-681
  • [28] Lorusso M., Cocco R., Sardanelli A.M., Minuto M., Bonomi F.,Papa S., Interaction of zinc ions with the bovine mitochondrialb-c1 complex, Eur. J. Biochem., 1991, 197, 555-561.
  • [29] Bonomi F., Iametti S., Kurtz D.M., Ragg E.M., Richie K.A., Directmetal ion substitution at the
  • [M(SCys)4]2- site of rubredoxin, J.Biol. Inorg. Chem., 1998, 3, 595-605.
  • [30] Valko M., Morris H., Cronin M.T.D., Metals, Toxicity andOxidative Stress, Current Medicinal Chemistry, 2005, 12,1161-1208.[WoS][Crossref]
  • [31] He M., Lu Y., Xu S., Mao L., Zhang L., Duan W., Liu C., Pi H.,Zhang Y., Zhong M., Yu Z., Zhou Z., MiRNA-210 modulates anickel-induced cellular energy metabolism shift by repressingthe iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2acells, Cell Death Dis., 2014, 5, e1090
  • [32] Pierik A.J., Netz D.J., Lill R., Analysis of iron-sulfur proteinmaturation in eukaryotes. Nat. Protoc., 2009, 4, 753-766.[Crossref]
  • [33] Lill R., Dutkiewicz R., Elsässer H.P., Hausmann A., Netz D.J.,Pierik A.J., Stehling O., Urzica E., Mühlenhoff U., Mechanismsof iron-sulfur protein maturation in mitochondria, cytosol andnucleus of eukaryotes, Biochim. Biophys. Acta, 2006, 1763,652-667.
  • [34] Shi H., Shi X., Liu K.J., Oxidative mechanism of arsenic toxicityand carcinogenesis, Mol Cell Biochem, 2004, 255(1-2), 67-78.
  • [35] He X. and Ma Q., Induction of Metallothionein I by Arsenic viaMetal-activated Transcription Factor 1, Jour of Biol Chem, 2009,284(19), 12609-12621.
  • [36] Vinceti M., Solovyev N., Mandrioli J., Crespi C.M., BonviciniF., Arcolin E., Georgoulopoulou E., Michalke B., Cerebrospinalfluid of newly diagnosed amyotrophic lateral sclerosis patientsexhibits abnormal levels of selenium species includingelevated selenite, NeuroToxicology, 2013, 38, 25–32.[WoS][Crossref]
  • [37] Hozumi I., Hasegawa T., Honda A., Ozawa K., Hayashi Y.,Hashimoto K., Yamada M., Koumura A., Sakurai T., KimuraA., et al., Patterns of levels of biological metals in CSF differamong neurodegenerative diseases, J Neurol Sci, 2011, 15,303(1-2):95-9.[WoS]
  • [38] Hadzhieva M., Kirches E., Wilisch-Neumann A., Pachow D.,Wallesch M., Schoenfeld P., Paege I., Vielhaber S., Petri S.,Keilhoff G., et al., Dysregulation of iron protein expression inthe G93A model of amyotrophic lateral sclerosis, Neuroscience,2013, 29;230, 94-101.[WoS]
  • [39] Veyrat-Durebex C., Corcia P., Mucha A., Benzimra S., Mallet C.,Gendrot C., Moreau C., Devos D., Piver E., Pagès J.C., et al., Ironmetabolism disturbance in a French cohort of ALS patients,Biomed Res Int, 2014, 2014:485723.[WoS]
  • [40] Nies D.H., Efflux-mediated heavy metal resistance inprokaryotes, FEMS Microbiol., 2003, Rev. 27, 313–339.[Crossref]
  • [41] Hashimoto K., Hayashi Y., Watabe K., Inuzuka T., Hozumi I.,Metallothionein-III prevents neuronal death and prolongslife span in Amyotrophic Lateral Sclerosis model mice,Neuroscience, 2011, 189, 293-298.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_ped-2015-0004
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