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2015 | 2 | 1 |

Article title

Serum metal evaluation in a small cohort of
Amyotrophic Lateral Sclerosis patients reveals
high levels of thiophylic species


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Amyotrophic Lateral Sclerosis (ALS) has often
been associated with improper/altered metal metabolism.
Analysis of thiophylic metals in serum from a small and
geographically restricted cohort of ALS patients indicates
contents of Pb and Ni much higher in patients than in
controls (Ni, 5-fold; Pb, 2-fold). Se levels are also higher in
the patients’ group, which has instead lower As levels than
controls. Thiophylic metals may impair biogenesis of FeS
clusters or substitute for iron, even in folded proteins; Se
may non-functionally replace S. Thus, improper assembly/
function of FeS proteins could represent another possible
issue to be considered in ALS pathogenesis.








Physical description


16 - 10 - 2015
20 - 1 - 2016
28 - 7 - 2015


  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • Department of Agricultural and Environmental
    Sciences (DiSAA), University of Milan, 20133 Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • Medical
    Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’
    Granda Hospital, 20169, Milan, Italy
  • NEuroMuscular Omnicentre (NEMO), Fondazione
    Serena Onlus, Niguarda Ca’ Granda Hospital, 20169, Milan, Italy
  • DeFENS, University of
    Milan, Via Celoria 2, 20133, Milan, Italy
  • Proteomics and Protein Structure Study Group,
    Division of Pharmacological Sciences, Department of Pharmacological
    and Biomolecular Sciences (DiSFeB), University of Milan, 20133
    Milano, Italy
  • Department of Food, Environmental
    and Nutritional Sciences (DeFENS), University of Milan,
    20133 Milan, Italy


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