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2015 | 2 | 1 |

Article title

Peptidomics in veterinary science: focus on bovine paratuberculosis


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Bacterial infections represent a serious burden
both for animal production and human health (zoonosis).
Faster and more reliable diagnosis are mandatory in order
to avoid economic losses and antibiotics misuse. The
development of new potential diagnostic strategies for
the immunodetection of pathogens is closely linked to
the discovery of small polypeptides with immunogenic
or immunoreactive activity. The candidate peptides used
for this purpose must have several properties principally
represented by their specificity and their location in
the bacterial cell. Both proteomics, peptidomics and
bioinformatics represent powerful complementary tools
to discover specific immunoreactive peptides useful for
diagnosis or vaccine. Peptidomics of Mycobacterium
avium subsp. paratuberculosis (MAP) represents a good
example of the potential of this discovery-phase. This
review reports a comprehensive update of the current
scientific knowledge about proteins and peptides of
MAP with already documented humoral response. These
findings, together with bioinformatics tools available,
could be extremely useful to design a better strategy
for subclinical bovine paratuberculosis diagnosis. The
knowledge provided also represents a reliable example
on the workflow to be followed in the direction of
the diagnosis of other diseases through a peptidomic








Physical description


3 - 10 - 2014
30 - 11 - 2014
30 - 3 - 2015


  • Dipartimento di Scienze
    Veterinarie e Sanità Pubblica, Università degli studi di Milano,
    Milano, Italy
  • Dipartimento di Scienze
    Veterinarie e Sanità Pubblica, Università degli studi di Milano,
    Milano, Italy
  • Fondazione Santa Lucia – IRCCS, Rome, Italy
  • Dipartimento di medicina sperimentale e chirurgia,
    Università degli studi di Roma TorVergata, Roma, Italy
  • Dipartimento di Scienze
    Veterinarie e Sanità Pubblica, Università degli studi di Milano,
    Milano, Italy
  • Dipartimento di Scienze
    Veterinarie e Sanità Pubblica, Università degli studi di Milano,
    Milano, Italy
  • Dipartimento di Scienze
    Veterinarie e Sanità Pubblica, Università degli studi di Milano,
    Milano, Italy
  • Istituto Sperimentale Italiano L. Spallanzani, Milano,


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